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Socs44A - Suppressor of Cytokine Signaling at 44A

Predicted to enable signaling adaptor activity. Involved in negative regulation of receptor signaling pathway via JAK-STAT and positive regulation of epidermal growth factor receptor signaling pathway. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval tracheal section; and oocyte. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; gastrointestinal system cancer (multiple); malaria; obesity; and reproductive organ cancer (multiple). Orthologous to several human genes including CISH (cytokine inducible SH2 containing protein); SOCS1 (suppressor of cytokine signaling 1); and SOCS2 (suppressor of cytokine signaling 2). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa