Mlh1 Mlh1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mlh1provided by FlyBase
Official Full Name: Mlh1provided by FlyBase
Primary source: FLYBASE:FBgn0011659
Locus tag: Dmel_CG11482
See related: AllianceGenome:FB:FBgn0011659
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11482; Dmel\CG11482; dmlh-1; dmlh1; mlh1; MLH1
Summary: Predicted to enable ATP hydrolysis activity. Predicted to be involved in mismatch repair. Predicted to be part of MutLalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer; mismatch repair cancer syndrome; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 44B8-44B8; 2-58 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8170274..8172401)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (4057779..4059906)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduction of the Mlh1 protein level leads to defective oocytes that fail to complete embryogenesis after fertilization thereby reducing female fertility.
Title: Mlh1 is required for female fertility in Drosophila melanogaster: An outcome of effects on meiotic crossing over, ovarian follicles and egg activation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables mismatched DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MutLalpha complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mismatch repair complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mlh1

Names: CG11482-PA; CG11482-PB; Mlh1-PA; Mlh1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

8170274..8172401

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273870.1 → NP_001260799.1 Mlh1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260799.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEM3, O61917

Conserved Domains (4) summary

cd00075
Location:33 → 115

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cd03483
Location:213 → 336

MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...

TIGR00585
Location:8 → 316

mutl; DNA mismatch repair protein MutL

pfam16413
Location:423 → 663

Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
NM_057674.3 → NP_477022.1 Mlh1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477022.1

Status: REVIEWED

UniProtKB/TrEMBL

A1Z7C1, O61917

Related

FBpp0087867

Conserved Domains (4) summary

cd00075
Location:33 → 115

HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

cd03483
Location:213 → 337

MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...

TIGR00585
Location:8 → 317

mutl; DNA mismatch repair protein MutL

pfam16413
Location:424 → 664

Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus