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pnut peanut [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35801, updated on 4-Jan-2025

Summary

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Official Symbol
pnutprovided by FlyBase
Official Full Name
peanutprovided by FlyBase
Primary source
FLYBASE:FBgn0013726
Locus tag
Dmel_CG8705
See related
AllianceGenome:FB:FBgn0013726
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-2.18; CG8705; clone 2.18; Dmel\CG8705; dSEPT7; E(sina)44C; E(sina)8; l(2)02502; Peanut; pnt; Pnut; PNUT
Summary
Enables several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein homodimerization activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; mitotic cytokinesis; and positive regulation of imaginal disc growth. Located in cleavage furrow; contractile ring; and intercellular bridge. Part of septin complex. Is expressed in adult head; central nervous system; follicle cell; furrow canal; and photoreceptor neurons. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See pnut in Genome Data Viewer
Location:
44C2-44C2; 2-58 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8237271..8240297)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4124776..4127802)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44275 Neighboring gene stable intronic sequence RNA CR46360 Neighboring gene deadpan Neighboring gene stable intronic sequence RNA 4 Neighboring gene long non-coding RNA:CR44276 Neighboring gene long non-coding RNA:CR44445

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Analysis of Phenotypic Manifestation of peanut Gene Expression Suppression by RNAi in Drosophila Oogenesis]. Akhmetova KA, et al. Genetika, 2015 Sep. PMID 26606795, Free PMC Article
  2. The Role of Pnut and its Functional Domains in Drosophila Spermatogenesis. Akhmetova KA, et al. Russ J Genet Appl Res, 2017 Jan. PMID 34306739, Free PMC Article
  3. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. Field CM, et al. J Cell Biol, 1996 May. PMID 8636235, Free PMC Article
  4. Purification and assay of a septin complex from Drosophila embryos. Oegema K, et al. Methods Enzymol, 1998. PMID 9751888
  5. Purification of cytoskeletal proteins using peptide antibodies. Field CM, et al. Methods Enzymol, 1998. PMID 9751906

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of Pnut in the early stages of Drosophila embryo development affects association of the Sep1-Sep2 complex with the membrane and is important for viability.
    Title: Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability.
  2. No oogenesis violations were observed in females with decreased peanut gene expression or an absence of the Pnut protein in the ovary generative cells
    Title: [Analysis of Phenotypic Manifestation of peanut Gene Expression Suppression by RNAi in Drosophila Oogenesis].
  3. These results show that the interaction of Orc6 with the septin complex is dependent on the coiled-coil domain of Pnut, and suggest an active role for Orc6 in septin complex function.
    Title: Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex.
  4. anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
    Title: Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
  5. Peanut is ubiquinated by Parkin and has a role in the neural cell death of autosomal recessive juvenile parkinsonism.
    Title: Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellularization TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in contractile ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peanut
Names
CG8705-PA
CG8705-PB
enhancer of seven in absentia 8
pnut-PA
pnut-PB
septin
septin 3
septin 7
septin[Pnut]

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8237271..8240297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165597.2 → NP_724659.1  peanut, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724659.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40797, Q0E9F5, Q9V385
    Related
    FBpp0087869
    Conserved Domains (2) summary
    COG5019
    Location:121 → 482
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:139 → 411
    Septin; Septin

  2. NM_057716.4 → NP_477064.1  peanut, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477064.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40797, Q0E9F5, Q9V385
    Related
    FBpp0087870
    Conserved Domains (2) summary
    COG5019
    Location:121 → 482
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    pfam00735
    Location:139 → 411
    Septin; Septin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40797.2 P40797

Gene LinkOut

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