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Lcp4 Larval cuticle protein 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35820, updated on 9-Dec-2024

Summary

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Official Symbol
Lcp4provided by FlyBase
Official Full Name
Larval cuticle protein 4provided by FlyBase
Primary source
FLYBASE:FBgn0002535
Locus tag
Dmel_CG2044
See related
AllianceGenome:FB:FBgn0002535
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4; CG2044; DmelLcp4; Dmel\CG2044; IV; LCP-4; lcp4; LCP4; L[[3]]CP4
Summary
A structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in integumentary system and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Lcp4 in Genome Data Viewer
Location:
44D1-44D1; 2-59 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8437647..8438495)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4325152..4326000)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 2 Neighboring gene Larval cuticle protein 3 Neighboring gene Cytochrome P450 4ad1 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of sex chromosomes: dosage compensation of the Lcp1-4 gene cluster on the evolving neo-X chromosome in Drosophila miranda. Steinemann S, et al. Insect Mol Biol, 2007 Apr. PMID 17352708
  2. Chromatin structure at the 44D larval cuticle gene locus in Drosophila: the effect of a transposable element insertion. Eissenberg JC, et al. Nucleic Acids Res, 1984 Dec 11. PMID 6096816, Free PMC Article
  3. The cuticle genes of drosophila: a developmentally regulated gene cluster. Snyder M, et al. Cell, 1981 Jul. PMID 6168386
  4. Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: II. Comparison at the amino acid sequence level. Steinemann M, et al. J Mol Evol, 1996 Oct. PMID 8798346
  5. Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the DNA sequence level. Steinemann M, et al. J Mol Evol, 1996 Oct. PMID 8798345

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural constituent of chitin-based larval cuticle IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of chitin-based larval cuticle IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of chitin-based larval cuticle ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chitin-based cuticle development ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in chitin-based extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chitin-based extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chitin-based extracellular matrix ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
larval cuticle protein 4
Names
CG2044-PA
CG2044-PB
Lcp4-PA
Lcp4-PB
cuticle p. IV
gene IV

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8437647..8438495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057274.4 → NP_476622.1  larval cuticle protein 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D0IQD9, P07189, Q9V4T2
    UniProtKB/TrEMBL
    A0A0B4KEM6
    Related
    FBpp0087823
    Conserved Domains (1) summary
    pfam00379
    Location:40 → 81
    Chitin_bind_4; Insect cuticle protein

  2. NM_001273875.1 → NP_001260804.1  larval cuticle protein 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260804.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D0IQD9, P07189, Q9V4T2
    UniProtKB/TrEMBL
    A0A0B4KEM6
    Conserved Domains (1) summary
    pfam00379
    Location:40 → 81
    Chitin_bind_4; Insect cuticle protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEM6 A0A0B4KEM6
P07189.2 P07189

Gene LinkOut

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