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Cyp4ad1 Cytochrome P450 4ad1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35821, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp4ad1provided by FlyBase
Official Full Name
Cytochrome P450 4ad1provided by FlyBase
Primary source
FLYBASE:FBgn0033292
Locus tag
Dmel_CG2110
See related
AllianceGenome:FB:FBgn0033292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4ad1; BEST:LD02646; CG2110; Cyp4AD1; CYP4AD1; Dmel\CG2110
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; gonad; and organism. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; endometriosis (multiple); ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Cyp4ad1 in Genome Data Viewer
Location:
44D1-44D1; 2-59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8439395..8442806, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4326900..4330311, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Larval cuticle protein 3 Neighboring gene Larval cuticle protein 4 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop Neighboring gene Cytochrome P450 4e1 Neighboring gene Maltase A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Davies L, et al. Insect Biochem Mol Biol, 2006 Oct. PMID 17027846
  2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
  3. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
  4. Phenotypic plasticity of the Drosophila transcriptome. Zhou S, et al. PLoS Genet, 2012. PMID 22479193, Free PMC Article
  5. Microarray analysis of Drosophila development during metamorphosis. White KP, et al. Science, 1999 Dec 10. PMID 10591654

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4ad1
Names
CG2110-PA
CG2110-PB
CYP4-related
Cyp4ad1-PA
Cyp4ad1-PB
cytochrome P450
NP_001260805.1
NP_610380.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8439395..8442806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136536.3 → NP_610380.1  cytochrome P450 4ad1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610380.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V4T3
    Related
    FBpp0087839
    Conserved Domains (1) summary
    pfam00067
    Location:36 → 470
    p450; Cytochrome P450

  2. NM_001273876.1 → NP_001260805.1  cytochrome P450 4ad1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260805.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUE5
    Conserved Domains (1) summary
    cl12078
    Location:4 → 235
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H1UUE5 H1UUE5
Q9V4T3.1 Q9V4T3

Gene LinkOut

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