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Mal-A5 Maltase A5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35828, updated on 4-Jan-2025

Summary

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Official Symbol
Mal-A5provided by FlyBase
Official Full Name
Maltase A5provided by FlyBase
Primary source
FLYBASE:FBgn0050359
Locus tag
Dmel_CG30359
See related
AllianceGenome:FB:FBgn0050359
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30359; CG8689; Dmel\CG30359; Drome_A5; Mal-5b; mal_A5
Summary
Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Mal-A5 in Genome Data Viewer
Location:
44D1-44D1; 2-59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8462753..8465092)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4350258..4352597)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A3 Neighboring gene Maltase A4 Neighboring gene Maltase A6 Neighboring gene Maltase A7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
  2. Ameliorative effect of bayberry leaves proanthocyanidins on high sugar diet induced Drosophila melanogaster. Wang M, et al. Front Pharmacol, 2022. PMID 36188544, Free PMC Article
  3. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
  4. Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression. Chng WA, et al. Cell Rep, 2014 Oct 9. PMID 25284780
  5. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Grönke S, et al. Cell Metab, 2005 May. PMID 16054079

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,4-glucosidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
maltase A5
Names
CG30359-PA
CG30359-PB
CG30359-PC
Mal-A5-PA
Mal-A5-PB
Mal-A5-PC
NP_001163088.1
NP_001286197.1
NP_610382.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8462753..8465092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169617.2 → NP_001163088.1  maltase A5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163088.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0N3
    Conserved Domains (2) summary
    cd11328
    Location:1 → 418
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    pfam00128
    Location:1 → 325
    Alpha-amylase; Alpha amylase, catalytic domain

  2. NM_136538.4 → NP_610382.2  maltase A5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610382.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5U124
    Related
    FBpp0087828
    Conserved Domains (2) summary
    cd11328
    Location:41 → 514
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    pfam00128
    Location:67 → 421
    Alpha-amylase; Alpha amylase, catalytic domain

  3. NM_001299268.1 → NP_001286197.1  maltase A5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286197.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEU9
    Conserved Domains (2) summary
    cd11328
    Location:41 → 495
    AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
    pfam00128
    Location:67 → 421
    Alpha-amylase; Alpha amylase, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LEU9 A0A0B4LEU9
Q5U124 Q5U124
Q8T0N3 Q8T0N3

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