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Cyp6a14 Cytochrome P450 6a14 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35835, updated on 9-Dec-2024

Summary

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Official Symbol
Cyp6a14provided by FlyBase
Official Full Name
Cytochrome P450 6a14provided by FlyBase
Primary source
FLYBASE:FBgn0033302
Locus tag
Dmel_CG8687
See related
AllianceGenome:FB:FBgn0033302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6a14; CG8687; Cyp6A14; CYP6A14; Dmel\CG8687
Old locus tag
Dmel_CR8687
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Cyp6a14 in Genome Data Viewer
Location:
44D3-44D3; 2-59 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8564187..8567202, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4451692..4454707, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45308 Neighboring gene pseudo Neighboring gene Cytochrome P450 6a13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Imidacloprid is hydroxylated by Laodelphax striatellus CYP6AY3v2. Wang R, et al. Insect Mol Biol, 2017 Oct. PMID 28654199
  2. Transcriptome analysis of Drosophila melanogaster laboratory strains of different geographical origin after long-term laboratory maintenance. Zarubin M, et al. Ecol Evol, 2020 Jul. PMID 32760513, Free PMC Article
  3. Stress response, behavior, and development are shaped by transposable element-induced mutations in Drosophila. Rech GE, et al. PLoS Genet, 2019 Feb. PMID 30753202, Free PMC Article
  4. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
  5. Comparative CYP-omic analysis between the DDT-susceptible and -resistant Drosophila melanogaster strains 91-C and 91-R. Seong KM, et al. Pest Manag Sci, 2018 Nov. PMID 29656515

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 6a14
Names
CG8687-PC
CG8687-PE
Cyp6a14-PC
Cyp6a14-PE
cytochrome P450
NP_001286199.1
  • frameshift
NP_610389.3
  • frameshift

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8564187..8567202 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299270.1 → NP_001286199.1  cytochrome P450 6a14, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286199.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LEW9, Q9V4U7
    UniProtKB/TrEMBL
    Q29QZ6
    Conserved Domains (1) summary
    pfam00067
    Location:32 → 506
    p450; Cytochrome P450

  2. NM_136545.3 → NP_610389.3  cytochrome P450 6a14, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610389.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4LEW9, Q9V4U7
    UniProtKB/TrEMBL
    Q29QZ6
    Conserved Domains (1) summary
    pfam00067
    Location:32 → 506
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V4U7.3 Q9V4U7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials