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CG8272 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35875, updated on 4-Jan-2025

Summary

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Official Symbol
CG8272provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033337
Locus tag
Dmel_CG8272
See related
AllianceGenome:FB:FBgn0033337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT8327; Dmel\CG8272; FBXL9
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in organism and spermatogonium. Orthologous to human FBXL9P (F-box and leucine rich repeat protein, pseudogene). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG8272 in Genome Data Viewer
Location:
44F2-44F3; 2-59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8888404..8891401, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4775909..4778906, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sticks and stones Neighboring gene uncharacterized protein Neighboring gene Ryanodine receptor Neighboring gene antisense RNA:CR45202 Neighboring gene Dynactin 2, p50 subunit Neighboring gene Secretory 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila ryanodine receptors mediate general anesthesia by halothane. Gao S, et al. Anesthesiology, 2013 Mar. PMID 23254148, Free PMC Article
  2. A conserved F-box gene with unusual transcript localization. Das T, et al. Dev Genes Evol, 2002 Apr. PMID 11976951
  3. F-box proteins: the key to protein degradation. Ho MS, et al. J Biomed Sci, 2006 Mar. PMID 16463014
  4. A systematic phenotypic screen of F-box genes through a tissue-specific RNAi-based approach in Drosophila. Dui W, et al. J Genet Genomics, 2012 Aug 20. PMID 22884096
  5. Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model. Park JE, et al. Exp Mol Med, 2023 Jul. PMID 37464094, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8272-PA
CG8272-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8888404..8891401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136569.4 → NP_610413.1  uncharacterized protein Dmel_CG8272, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610413.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K0V7
    Related
    FBpp0087767
    Conserved Domains (4) summary
    cd09293
    Location:515 → 642
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:322 → 346
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:12 → 44
    F-box-like; F-box-like
    cl14603
    Location:231 → 274
    C2; C2 domain

  2. NM_001273883.2 → NP_001260812.1  uncharacterized protein Dmel_CG8272, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEH1
    Conserved Domains (4) summary
    cd09293
    Location:515 → 642
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:322 → 346
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:12 → 44
    F-box-like; F-box-like
    cl14603
    Location:231 → 274
    C2; C2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEH1 A0A0B4KEH1
Q7K0V7 Q7K0V7

Gene LinkOut

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