U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CCT8 Chaperonin containing TCP1 subunit 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35882, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
CCT8provided by FlyBase
Official Full Name
Chaperonin containing TCP1 subunit 8provided by FlyBase
Primary source
FLYBASE:FBgn0284436
Locus tag
Dmel_CG8258
See related
AllianceGenome:FB:FBgn0284436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cct8; CG8258; Dmel\CG8258; l(2)03996; Q7K3J0_DROME; TCP-1theta; Tcp1-theta; TCP1-theta
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult brain cell body rind; adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human CCT8 (chaperonin containing TCP1 subunit 8). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CCT8 in Genome Data Viewer
Location:
44F5-44F5; 2-59 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8904844..8906990, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4792349..4794495, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene MRG/MORF4L binding protein Neighboring gene G protein gamma subunit 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphoglucose isomerase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Ortega JA, et al. Neuron, 2020 Apr 8. PMID 32059759, Free PMC Article
  2. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article
  3. Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Plimpton RL, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675501, Free PMC Article
  4. CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease. Lottes EN, et al. Cells, 2024 Jun 13. PMID 38920658, Free PMC Article
  5. TRiC/CCT chaperonins are essential for organ growth by interacting with insulin/TOR signaling in Drosophila. Kim AR, et al. Oncogene, 2019 Jun. PMID 30792539, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
chaperonin containing TCP1 subunit 8
Names
CCT8-PA
CG8258-PA
lethal (2) 03996

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8904844..8906990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136574.3 → NP_610418.1  chaperonin containing TCP1 subunit 8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610418.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3J0
    Related
    FBpp0087764
    Conserved Domains (2) summary
    cd03341
    Location:20 → 529
    TCP1_theta; TCP-1 (CTT or eukaryotic type II) chaperonin family, theta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    pfam00118
    Location:40 → 529
    Cpn60_TCP1; TCP-1/cpn60 chaperonin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3J0 Q7K3J0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous