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Np Notopleural [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35904, updated on 9-Dec-2024

Summary

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Official Symbol
Npprovided by FlyBase
Official Full Name
Notopleuralprovided by FlyBase
Primary source
FLYBASE:FBgn0265011
Locus tag
Dmel_CG34350
See related
AllianceGenome:FB:FBgn0265011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11824; CG34350; CG8181; cSP59; Dmel\CG34350; np; SP59
Old locus tag
CG11824; CG8181; Dmel_CG11824; Dmel_CG8181
Summary
Enables serine-type peptidase activity. Involved in liquid clearance, open tracheal system. Located in apical plasma membrane and extracellular space. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic ventral epidermis; epithelium; and gut section. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
45A1-45A1; 2-60 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8992945..9006587, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4880450..4894092, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene space blanket Neighboring gene filzig Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic incompatibilities are widespread within species. Corbett-Detig RB, et al. Nature, 2013 Dec 5. PMID 24196712, Free PMC Article
  2. Control of tissue morphogenesis by the HOX gene Ultrabithorax. Diaz-de-la-Loza MD, et al. Development, 2020 Mar 2. PMID 32122911, Free PMC Article
  3. Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis. Drees L, et al. PLoS Genet, 2019 Jan. PMID 30601807, Free PMC Article
  4. Spatiotemporal remodeling of extracellular matrix orients epithelial sheet folding. Tsuboi A, et al. Sci Adv, 2023 Sep. PMID 37656799, Free PMC Article
  5. CopyCatchers are versatile active genetic elements that detect and quantify inter-homolog somatic gene conversion. Li Z, et al. Nat Commun, 2021 May 11. PMID 33976171, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we demonstrate that Tpr zymogen and the ZP domain of the ECM protein Piopio are cleaved by Np and matriptase in vitro.
    Title: Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables serine-type peptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in liquid clearance, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
notopleural
Names
CG34350-PA
CG34350-PB
Np-PA
Np-PB
NP_001246213.1
NP_610437.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8992945..9006587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259284.2 → NP_001246213.1  notopleural, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246213.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7M3
    Conserved Domains (2) summary
    smart00020
    Location:797 → 1035
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:798 → 1038
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_136593.3 → NP_610437.2  notopleural, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610437.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7M3
    Conserved Domains (2) summary
    smart00020
    Location:797 → 1035
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:798 → 1038
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7M3 A1Z7M3

Gene LinkOut

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