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Dbp45A DEAD box protein 45A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35917, updated on 4-Jan-2025

Summary

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Official Symbol
Dbp45Aprovided by FlyBase
Official Full Name
DEAD box protein 45Aprovided by FlyBase
Primary source
FLYBASE:FBgn0010220
Locus tag
Dmel_CG12759
See related
AllianceGenome:FB:FBgn0010220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12759; Dbp45; dbp45A; DBP45A; DDX49; Dmel\CG12759; DmRH18
Summary
Predicted to enable RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in organism. Orthologous to human DDX49 (DEAD-box helicase 49). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Dbp45A in Genome Data Viewer
Location:
45A1-45A2; 2-60 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9087834..9089802)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4975339..4977307)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Concentrative nucleoside transporter 2 Neighboring gene Concentrative nucleoside transporter 1 Neighboring gene uncharacterized protein Neighboring gene NAD kinase 2, mitochondrial Neighboring gene ncRNA Neighboring gene Bootlegger Neighboring gene U snoRNA host gene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dbp45A encodes a Drosophila DEAD box protein with similarity to a putative yeast helicase involved in ribosome assembly. Lavoie CA, et al. Biochim Biophys Acta, 1993 Oct 19. PMID 7692973
  2. A novel DEAD-box RNA helicase exhibits high sequence conservation from yeast to humans. Eisen A, et al. Biochim Biophys Acta, 1998 Apr 29. PMID 9565667
  3. DDX56 Binds to Chikungunya Virus RNA To Control Infection. Taschuk F, et al. mBio, 2020 Oct 27. PMID 33109765, Free PMC Article
  4. Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Moy RH, et al. Cell, 2014 Aug 14. PMID 25126784, Free PMC Article
  5. DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner. Fortuna TR, et al. Acta Neuropathol, 2021 Sep. PMID 34061233, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
DEAD box protein 45A
Names
ATP-dependent RNA helicase
CG12759-PA
Dbp45A-PA
NP_476927.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9087834..9089802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057579.5 → NP_476927.1  DEAD box protein 45A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476927.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07886, Q9V528
    Related
    FBpp0087645
    Conserved Domains (3) summary
    COG0513
    Location:8 → 490
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00268
    Location:9 → 197
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:239 → 346
    Helicase_C; Helicase conserved C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07886.2 Q07886

Gene LinkOut

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