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Nadk2 NAD kinase 2, mitochondrial [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35918, updated on 9-Dec-2024

Summary

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Official Symbol
Nadk2provided by FlyBase
Official Full Name
NAD kinase 2, mitochondrialprovided by FlyBase
Primary source
FLYBASE:FBgn0033373
Locus tag
Dmel_CG8080
See related
AllianceGenome:FB:FBgn0033373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG30346; CG8080; Dmel\CG8080; NADK2
Summary
Predicted to enable NAD+ kinase activity. Predicted to be involved in NAD metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult brain; adult pars intercerebralis; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Orthologous to human NADK2 (NAD kinase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nadk2 in Genome Data Viewer
Location:
45A2-45A2; 2-60 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9089774..9092893, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4977279..4980398, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Concentrative nucleoside transporter 2 Neighboring gene Concentrative nucleoside transporter 1 Neighboring gene uncharacterized protein Neighboring gene DEAD box protein 45A Neighboring gene ncRNA Neighboring gene Bootlegger Neighboring gene ncRNA Neighboring gene U snoRNA host gene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NAD kinase sustains lipogenesis and mitochondrial metabolismthrough fatty acid synthesis. Xu M, et al. Cell Rep, 2021 Dec 28. PMID 34965438
  2. Functional genomic analysis of the periodic transcriptome in the developing Drosophila wing. Liang L, et al. Dev Cell, 2014 Apr 14. PMID 24684830
  3. A gene-specific T2A-GAL4 library for Drosophila. Lee PT, et al. Elife, 2018 Mar 22. PMID 29565247, Free PMC Article
  4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
  5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD+ kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in NAD metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in NAD metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NAD kinase 2, mitochondrial
Names
CG8080-PA
CG8080-PB
CG8080-PC
CG8080-PD
CG8080-PE
Nadk2-PA
Nadk2-PB
Nadk2-PC
Nadk2-PD
Nadk2-PE
NP_001260815.1
NP_001260816.1
NP_001260817.1
NP_001260818.1
NP_788288.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9089774..9092893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273887.2 → NP_001260816.1  NAD kinase 2, mitochondrial, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260816.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF27
    Conserved Domains (1) summary
    cl01255
    Location:106 → 283
    DAGK_cat; Diacylglycerol kinase catalytic domain

  2. NM_176108.2 → NP_788288.1  NAD kinase 2, mitochondrial, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788288.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JW73
    Related
    FBpp0087714
    Conserved Domains (1) summary
    cl01255
    Location:71 → 288
    DAGK_cat; Diacylglycerol kinase catalytic domain

  3. NM_001273886.1 → NP_001260815.1  NAD kinase 2, mitochondrial, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260815.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFF1
    Conserved Domains (1) summary
    cl01255
    Location:107 → 284
    DAGK_cat; Diacylglycerol kinase catalytic domain

  4. NM_001273888.1 → NP_001260817.1  NAD kinase 2, mitochondrial, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260817.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEH3
    Conserved Domains (1) summary
    cl01255
    Location:107 → 284
    DAGK_cat; Diacylglycerol kinase catalytic domain

  5. NM_001273889.1 → NP_001260818.1  NAD kinase 2, mitochondrial, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260818.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEG0
    Conserved Domains (1) summary
    cl01255
    Location:71 → 288
    DAGK_cat; Diacylglycerol kinase catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEG0 A0A0B4KEG0
A0A0B4KEH3 A0A0B4KEH3
A0A0B4KF27 A0A0B4KF27
A0A0B4KFF1 A0A0B4KFF1
Q7JW73 Q7JW73

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