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VhaAC45 Vacuolar H[+] ATPase AC45 accessory subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35944, updated on 4-Jan-2025

Summary

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Official Symbol
VhaAC45provided by FlyBase
Official Full Name
Vacuolar H[+] ATPase AC45 accessory subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0262515
Locus tag
Dmel_CG8029
See related
AllianceGenome:FB:FBgn0262515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.117; ATP6AP1; CG8029; Dmel\CG8029; l(2)SH1634; l(2)SH2 1634; vhaAC45
Summary
Predicted to enable ATPase activator activity. Involved in vacuolar proton-transporting V-type ATPase complex assembly. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; larval muscle system; and midgut. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to several human genes including ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See VhaAC45 in Genome Data Viewer
Location:
45B4-45B4; 2-60 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9207561..9209774)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5095066..5097279)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene unplugged Neighboring gene N-acetylglucosamine-1-phosphate transferase subunits alpha and beta Neighboring gene long non-coding RNA:CR45309 Neighboring gene long non-coding RNA:CR44451

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATP6AP2 functions as a V-ATPase assembly factor in the endoplasmic reticulum. Guida MC, et al. Mol Biol Cell, 2018 Sep 1. PMID 29995586, Free PMC Article
  2. Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects. Rujano MA, et al. J Exp Med, 2017 Dec 4. PMID 29127204, Free PMC Article
  3. Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster. Tognon E, et al. Autophagy, 2016. PMID 26727288, Free PMC Article
  4. A Novel Neuron-Specific Regulator of the V-ATPase in Drosophila. Dulac A, et al. eNeuro, 2021 Sep-Oct. PMID 34620624, Free PMC Article
  5. The conserved microRNA miR-8-3p coordinates the expression of V-ATPase subunits to regulate ecdysone biosynthesis for Drosophila metamorphosis. Lim DH, et al. FASEB J, 2020 May. PMID 32196731

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of cellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
vacuolar H[+] ATPase AC45 accessory subunit
Names
CG8029-PA
CG8029-PB
VhaAC45-PA
VhaAC45-PB
lethal (2) SH1634
vacuolar H[+] ATPase accessory protein AC45

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9207561..9209774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136626.5 → NP_610470.1  vacuolar H[+] ATPase AC45 accessory subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610470.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JR49
    Related
    FBpp0087668
    Conserved Domains (1) summary
    pfam05827
    Location:244 → 376
    ATP-synt_S1; Vacuolar ATP synthase subunit S1 (ATP6S1)

  2. NM_165665.2 → NP_724770.1  vacuolar H[+] ATPase AC45 accessory subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JR49
    Related
    FBpp0087669
    Conserved Domains (1) summary
    pfam05827
    Location:244 → 376
    ATP-synt_S1; Vacuolar ATP synthase subunit S1 (ATP6S1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JR49.1 Q7JR49

Gene LinkOut

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