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Pkn Protein kinase N [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35950, updated on 9-Dec-2024

Summary

Official Symbol
Pknprovided by FlyBase
Official Full Name
Protein kinase Nprovided by FlyBase
Primary source
FLYBASE:FBgn0020621
Locus tag
Dmel_CG2049
See related
AllianceGenome:FB:FBgn0020621
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
3-2; CG2049; CG2055; CG8; CT6637; CT6660; Dmel\CG2049; dPKN; Dpkn; DPKN; l(2)06736; l(2)45Ca; Pk45C; Pk?3; PKC-related; pkn; PKN; PRK2; v(2)rG232
Summary
Enables protein kinase activity. Involved in several processes, including dorsal closure; mitotic cytokinesis, division site positioning; and protein autophosphorylation. Located in apical cortex. Is expressed in several structures, including adult brain cell body rind; adult head; embryonic/larval anterior spiracle; embryonic/larval mouth; and embryonic/larval pharynx. Orthologous to several human genes including PKN2 (protein kinase N2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Pkn in Genome Data Viewer
Location:
45C1-45C1; 2-60 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9252310..9285097, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5139815..5172602, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene hikaru genki Neighboring gene Cytochrome P450 4p1 Neighboring gene Cytochrome P450 4p3 Neighboring gene tRNA splicing endonuclease subunit 15 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45132 Neighboring gene uncharacterized protein Neighboring gene Component of oligomeric golgi complex 6 Neighboring gene Mitotic arrest-deficient 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cytokinesis, division site positioning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in wing disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol HDA PubMed 

General protein information

Preferred Names
protein kinase N
Names
CG2049-PB
CG2049-PC
CG2049-PD
CG2049-PE
CG2049-PF
CG2049-PG
CG2049-PH
CG2049-PJ
CG2049-PK
CG2049-PL
CG2049-PM
CG2049-PN
CG2049-PO
CG2049-PP
CG2049-PQ
CG2049-PS
Pkn-PB
Pkn-PC
Pkn-PD
Pkn-PE
Pkn-PF
Pkn-PG
Pkn-PH
Pkn-PJ
Pkn-PK
Pkn-PL
Pkn-PM
Pkn-PN
Pkn-PO
Pkn-PP
Pkn-PQ
Pkn-PS
complementation group 8
protein kinase c related
protein kinase related to protein kinase N
protein kinase-like 45C
NP_001097237.1
NP_001163095.1
NP_001188895.1
NP_001188896.1
NP_001188897.3
NP_001246220.1
NP_001246221.1
NP_001286241.1
NP_001286242.1
NP_001286243.1
NP_001286244.1
NP_788290.1
NP_788291.1
NP_788292.1
NP_788293.2
NP_788294.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9252310..9285097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176110.2NP_788290.1  protein kinase N, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788290.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z7T0, C7LA81
    Related
    FBpp0087682
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:8631122
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:8631188
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  2. NM_176112.2NP_788292.1  protein kinase N, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788292.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7T2
    Related
    FBpp0087684
    Conserved Domains (6) summary
    cd11622
    Location:52115
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:164230
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:261335
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:8781137
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:8781203
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:451532
    C2; C2 domain
  3. NM_176113.3NP_788293.2  protein kinase N, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788293.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7T3
    Conserved Domains (6) summary
    cd11622
    Location:52115
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:164230
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:261335
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:10951354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:10951420
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:451532
    C2; C2 domain
  4. NM_001169624.1NP_001163095.1  protein kinase N, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163095.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JH15
    Conserved Domains (6) summary
    cd11622
    Location:131194
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:243309
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:340414
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:9571216
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:9571282
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:530611
    C2; C2 domain
  5. NM_001201967.1NP_001188896.1  protein kinase N, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188896.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD07, A0A0B4JD60
    Conserved Domains (6) summary
    cd11622
    Location:131194
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:243309
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:340414
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:10271286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:10271352
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:530611
    C2; C2 domain
  6. NM_001103767.2NP_001097237.1  protein kinase N, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097237.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY76
    Conserved Domains (6) summary
    cd11622
    Location:131194
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:243309
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:340414
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:11741433
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:11741499
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:530611
    C2; C2 domain
  7. NM_176114.3NP_788294.1  protein kinase N, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788294.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7T4, Q7YU74
    Related
    FBpp0087686
    Conserved Domains (2) summary
    smart00220
    Location:263522
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:263588
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
  8. NM_001299313.1NP_001286242.1  protein kinase N, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286242.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEY5
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:8401099
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:8401165
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  9. NM_001259291.2NP_001246220.1  protein kinase N, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246220.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6U3
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:9331192
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:9331258
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  10. NM_001299315.1NP_001286244.1  protein kinase N, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286244.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LF03
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:9511210
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:9511276
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  11. NM_001299314.1NP_001286243.1  protein kinase N, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEI8
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:9531212
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:9531278
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  12. NM_176111.2NP_788291.1  protein kinase N, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788291.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7T1, Q960L7
    Related
    FBpp0087683
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:10801339
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:10801405
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  13. NM_001299312.1NP_001286241.1  protein kinase N, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286241.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFX2
    Conserved Domains (6) summary
    cd11622
    Location:37100
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:149215
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:246320
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:11501409
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:11501475
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:436517
    C2; C2 domain
  14. NM_001259292.2NP_001246221.1  protein kinase N, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246221.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K727
    Conserved Domains (6) summary
    cd11622
    Location:52115
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:164230
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:261335
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:9481207
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:9481273
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:451532
    C2; C2 domain
  15. NM_001201966.2NP_001188895.1  protein kinase N, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K727
    Conserved Domains (6) summary
    cd11622
    Location:52115
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:164230
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:261335
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:9481207
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:9481273
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:451532
    C2; C2 domain
  16. NM_001201968.3NP_001188897.3  protein kinase N, isoform S [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD07, A0A0B4JD60
    Conserved Domains (6) summary
    cd11622
    Location:131194
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11623
    Location:243309
    HR1_PKN_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11625
    Location:340414
    HR1_PKN_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    smart00220
    Location:10271286
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:10271352
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl14603
    Location:530611
    C2; C2 domain