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slc34a2b solute carrier family 34 member 2b [ Danio rerio (zebrafish) ]

Gene ID: 359838, updated on 4-Jan-2025

Summary

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Official Symbol
slc34a2bprovided by ZNC
Official Full Name
solute carrier family 34 member 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030709-1
See related
Ensembl:ENSDARG00000036864 AllianceGenome:ZFIN:ZDB-GENE-030709-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
NaPi-IIb2; wu:fi68d06
Summary
Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane. Is expressed in several structures, including digestive system; endoderm; optic vesicle; otic placode; and otic vesicle. Human ortholog(s) of this gene implicated in pulmonary alveolar microlithiasis. Orthologous to human SLC34A2 (solute carrier family 34 member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See slc34a2b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (1075252..1106138)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (1068952..1094122)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:zfos-905g2.1 Neighboring gene zgc:113423 Neighboring gene protein FAM13A-like Neighboring gene uncharacterized LOC137489066 Neighboring gene protein sel-1 homolog 3 Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene proteasome 20S subunit beta 11b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular determinants of transport function in zebrafish Slc34a Na-phosphate transporters. Werner A, et al. Am J Physiol Regul Integr Comp Physiol, 2016 Dec 1. PMID 27784684
  2. Processing of naturally occurring sense/antisense transcripts of the vertebrate Slc34a gene into short RNAs. Carlile M, et al. Physiol Genomics, 2008 Jun 12. PMID 18413783
  3. Ectopically expressed Slc34a2a sense-antisense transcripts cause a cerebellar phenotype in zebrafish embryos depending on RNA complementarity and Dicer. Piatek MJ, et al. PLoS One, 2017. PMID 28542524, Free PMC Article
  4. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sodium:phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium:phosphate symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular phosphate ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphate ion transport IDA
Inferred from Direct Assay
more info
  
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium-dependent phosphate transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
  
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 34 member 2b
Names
solute carrier family 34 (sodium phosphate), member 2b
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182877.2 → NP_878297.1  solute carrier family 34 member 2b

    See identical proteins and their annotated locations for NP_878297.1

    Status: PROVISIONAL

    Source sequence(s)
    AF297180
    UniProtKB/TrEMBL
    Q9DDS6
    Related
    ENSDARP00000139464.2, ENSDART00000159263.2
    Conserved Domains (2) summary
    TIGR01013
    Location:90 → 585
    2a58; Phosphate:Na+ Symporter (PNaS) Family
    pfam02690
    Location:398 → 455
    Na_Pi_cotrans; Na+/Pi-cotransporter

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    1075252..1106138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469757.2 → XP_021325432.1  solute carrier family 34 member 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M9P515
    Conserved Domains (1) summary
    TIGR01013
    Location:90 → 585
    2a58; Phosphate:Na+ Symporter (PNaS) Family

  2. XM_068216694.1 → XP_068072795.1  solute carrier family 34 member 2b isoform X1

    UniProtKB/TrEMBL
    A0A8M9P515
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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