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Nt5c 5' nucleotidase C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35984, updated on 4-Jan-2025

Summary

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Official Symbol
Nt5cprovided by FlyBase
Official Full Name
5' nucleotidase Cprovided by FlyBase
Primary source
FLYBASE:FBgn0033426
Locus tag
Dmel_CG1814
See related
AllianceGenome:FB:FBgn0033426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
45550393; 45551045; CG1814; Dmel\CG1814; dNT5C
Summary
Predicted to enable 5'-nucleotidase activity and single-stranded DNA binding activity. Predicted to be involved in DNA damage response. Predicted to be located in mitochondrial matrix and nucleus. Is expressed in several structures, including adult head; adult heart; larval muscle cell; and larval muscle system. Orthologous to human NT5DC2 (5'-nucleotidase domain containing 2) and NT5DC3 (5'-nucleotidase domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Nt5c in Genome Data Viewer
Location:
45F4-45F4; 2-61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9577427..9581847)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5464932..5469352)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45281 Neighboring gene Odorant receptor 45b Neighboring gene Alkaline phosphatase 6 Neighboring gene Not1 Neighboring gene long non-coding RNA:CR46257 Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene uncharacterized protein Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene Ribosomal protein L31 Neighboring gene closca

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr). Singgih EL, et al. Transl Psychiatry, 2021 Jan 18. PMID 33462198, Free PMC Article
  2. Modifiers of notch transcriptional activity identified by genome-wide RNAi. Mourikis P, et al. BMC Dev Biol, 2010 Oct 19. PMID 20959007, Free PMC Article
  3. Expression of cardiac myosin-binding protein-C (cMyBP-C) in Drosophila as a model for the study of human cardiomyopathies. Vu Manh TP, et al. Hum Mol Genet, 2005 Jan 1. PMID 15525659
  4. Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing. Ostalé CM, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599799, Free PMC Article
  5. Proteomic Analysis of the Ubiquitin Landscape in the Drosophila Embryonic Nervous System and the Adult Photoreceptor Cells. Ramirez J, et al. PLoS One, 2015. PMID 26460970, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial matrix ISM
Inferred from Sequence Model
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
5' nucleotidase C
Names
CG1814-PA
CG1814-PB
CG1814-PC
Nt5c-PA
Nt5c-PB
Nt5c-PC
NP_610499.2
NP_724800.1
NP_724801.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9577427..9581847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165680.2 → NP_724801.2  5' nucleotidase C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724801.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7V8, C6SV33
    Related
    FBpp0087604
    Conserved Domains (1) summary
    pfam05761
    Location:22 → 457
    5_nucleotid; 5' nucleotidase family

  2. NM_136655.4 → NP_610499.2  5' nucleotidase C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610499.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7V9, C6SV33
    Related
    FBpp0087605
    Conserved Domains (1) summary
    pfam05761
    Location:108 → 543
    5_nucleotid; 5' nucleotidase family

  3. NM_165679.3 → NP_724800.1  5' nucleotidase C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724800.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6SV33, Q7K3S2
    Related
    FBpp0087606
    Conserved Domains (1) summary
    pfam05761
    Location:2 → 404
    5_nucleotid; 5' nucleotidase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7V8 A1Z7V8
A1Z7V9 A1Z7V9
Q7K3S2 Q7K3S2

Gene LinkOut

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