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Rhebl1 RHEB like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 359959, updated on 27-Nov-2024

Summary

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Official Symbol
Rhebl1provided by RGD
Official Full Name
RHEB like 1provided by RGD
Primary source
RGD:727778
See related
EnsemblRapid:ENSRNOG00000054385 AllianceGenome:RGD:727778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in TOR signaling; positive regulation of NF-kappaB transcription factor activity; and small GTPase-mediated signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human RHEBL1 (RHEB like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 20.8), Spleen (RPKM 20.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rhebl1 in Genome Data Viewer
Location:
7q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (131905207..131910088, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (130026255..130031127, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (140552704..140556980, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1C Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene lysine methyltransferase 2D Neighboring gene limb development membrane protein 1-like Neighboring gene desert hedgehog signaling molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B. Yuan J, et al. Mol Biol Rep, 2005 Dec. PMID 16328882
  2. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. Tabancay AP Jr, et al. J Biol Chem, 2003 Oct 10. PMID 12869548
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTPase RhebL1
Names
Ras homolog enriched in brain like 1
ras homolog enriched in brain-like protein 1
rheb-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182825.2 → NP_877977.1  GTPase RhebL1

    See identical proteins and their annotated locations for NP_877977.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q7TNZ5
    UniProtKB/TrEMBL
    A6KCC3
    Related
    ENSRNOP00000074953.2, ENSRNOT00000089523.3
    Conserved Domains (2) summary
    smart00010
    Location:5 → 169
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04137
    Location:6 → 183
    RheB; Ras Homolog Enriched in Brain (RheB) is a small GTPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    131905207..131910088 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079359.2 → XP_038935287.2  GTPase RhebL1 isoform X3

  2. XM_039079358.2 → XP_038935286.2  GTPase RhebL1 isoform X2

  3. XM_008765754.4 → XP_008763976.2  GTPase RhebL1 isoform X1

  4. XM_008765755.4 → XP_008763977.2  GTPase RhebL1 isoform X4

RNA

  1. XR_010052989.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNZ5.1 GenPept UniProtKB/Swiss-Prot:Q7TNZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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