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Uba1 - Ubiquitin activating enzyme 1

Enables ubiquitin activating enzyme activity. Involved in several processes, including larval midgut cell programmed cell death; mitophagy; and nervous system development. Located in dendrite. Is expressed in several structures, including CNS glial cell; ganglia; gut section; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa