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Uba1 - Ubiquitin activating enzyme 1

Enables ubiquitin activating enzyme activity. Involved in several processes, including larval midgut cell programmed cell death; nervous system development; and regulation of Ras protein signal transduction. Located in dendrite. Is expressed in several structures, including CNS glial cell; Malpighian tubule primordium; ganglia; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to several human genes including UBA1 (ubiquitin like modifier activating enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa