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CG10459 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36000, updated on 4-Jan-2025

Summary

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Official Symbol
CG10459provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033440
Locus tag
Dmel_CG10459
See related
AllianceGenome:FB:FBgn0033440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10459
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in protein polyubiquitination. Predicted to be part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG10459 in Genome Data Viewer
Location:
46A1-46A1; 2-61 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9707536..9708722)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5595041..5596227)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin activating enzyme 1 Neighboring gene long non-coding RNA:CR44292 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dacapo Neighboring gene spaghetti-squash activator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deletion-generator compound element allows deletion saturation analysis for genomewide phenotypic annotation. Huet F, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12096187, Free PMC Article
  2. A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. Dubruille R, et al. PLoS Genet, 2009 Dec. PMID 20041201, Free PMC Article
  3. The Hippo pathway promotes cell survival in response to chemical stress. Di Cara F, et al. Cell Death Differ, 2015 Sep. PMID 26021298, Free PMC Article
  4. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article
  5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10459-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9707536..9708722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136669.4 → NP_610513.2  uncharacterized protein Dmel_CG10459 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610513.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Y4, Q3ZAL0
    Related
    FBpp0087552
    Conserved Domains (3) summary
    COG2319
    Location:10 → 322
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:61 → 97
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:11 → 297
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7Y4 A1Z7Y4

Gene LinkOut

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