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AURKB aurora kinase B [ Bos taurus (domestic cattle) ]

Gene ID: 360192, updated on 29-Jan-2025

Summary

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Official Symbol
AURKBprovided by VGNC
Official Full Name
aurora kinase Bprovided by VGNC
Primary source
VGNC:VGNC:26351
See related
BGD:BT17075; Ensembl:ENSBTAG00000001717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
AIM-1; ARK-2; STK-1; STK12
Orthologs
human mouse all
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Genomic context

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See AURKB in Genome Data Viewer
Location:
chromosome: 19
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (27835751..27840837, complement)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC104975022 Neighboring gene transfer RNA isoleucine (anticodon AAU) Neighboring gene BLOC-1 related complex subunit 6 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene transfer RNA glycine (anticodon UCC)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B. Luciano AM, et al. Biol Reprod, 2013 Mar. PMID 23325810, Free PMC Article
  2. Progesterone receptor membrane component 1 expression and putative function in bovine oocyte maturation, fertilization, and early embryonic development. Luciano AM, et al. Reproduction, 2010 Nov. PMID 20739377
  3. ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C. Carlton JG, et al. Science, 2012 Apr 13. PMID 22422861, Free PMC Article
  4. Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation. Uzbekova S, et al. Biol Reprod, 2008 Feb. PMID 17687118
  5. ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4. Thoresen SB, et al. Nat Cell Biol, 2014 Jun. PMID 24814515

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alterations in PGRMC1 and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
    Title: Oocytes isolated from dairy cows with reduced ovarian reserve have a high frequency of aneuploidy and alterations in the localization of progesterone receptor membrane component 1 and aurora kinase B.
  2. AURKB associated with metaphase chromosomes.
    Title: Spatio-temporal expression patterns of aurora kinases a, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC142782

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic spindle organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromosome passenger complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle midzone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in spindle pole centrosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
aurora kinase B
Names
aurora 1
aurora- and IPL1-like midbody-associated protein 1
aurora-B
aurora-related kinase 2
aurora/IPL1-related kinase 2
serine/threonine kinase 12
serine/threonine-protein kinase 12
serine/threonine-protein kinase 5
serine/threonine-protein kinase aurora-B
NP_898907.2
XP_005220363.1
XP_010814291.1
XP_010814292.1
XP_015314161.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183084.2 → NP_898907.2  aurora kinase B

    See identical proteins and their annotated locations for NP_898907.2

    Status: PROVISIONAL

    Source sequence(s)
    BC123650
    UniProtKB/Swiss-Prot
    Q7YRC6
    UniProtKB/TrEMBL
    Q08DN4
    Related
    ENSBTAP00070025493.1, ENSBTAT00070042687.1
    Conserved Domains (1) summary
    cd14117
    Location:70 → 339
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    27835751..27840837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010815989.4 → XP_010814291.1  aurora kinase B isoform X1

    See identical proteins and their annotated locations for XP_010814291.1

    UniProtKB/Swiss-Prot
    Q7YRC6
    UniProtKB/TrEMBL
    Q08DN4
    Conserved Domains (1) summary
    cd14117
    Location:70 → 339
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

  2. XM_010815990.4 → XP_010814292.1  aurora kinase B isoform X2

    See identical proteins and their annotated locations for XP_010814292.1

    UniProtKB/TrEMBL
    F6QLP7
    Related
    ENSBTAP00070025470.1, ENSBTAT00070042657.1
    Conserved Domains (1) summary
    cd14117
    Location:29 → 298
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

  3. XM_005220306.5 → XP_005220363.1  aurora kinase B isoform X1

    See identical proteins and their annotated locations for XP_005220363.1

    UniProtKB/Swiss-Prot
    Q7YRC6
    UniProtKB/TrEMBL
    Q08DN4
    Related
    ENSBTAP00070025489.1, ENSBTAT00070042680.1
    Conserved Domains (1) summary
    cd14117
    Location:70 → 339
    STKc_Aurora-B_like; Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins

  4. XM_015458675.2 → XP_015314161.1  aurora kinase B isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:21 → 187
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YRC6.1 GenPept UniProtKB/Swiss-Prot:Q7YRC6

Gene LinkOut

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