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CG12744 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36024, updated on 9-Dec-2024

Summary

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Official Symbol
CG12744provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033459
Locus tag
Dmel_CG12744
See related
AllianceGenome:FB:FBgn0033459
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG12744
Summary
Involved in defense response to fungus. Is expressed in embryonic/larval salivary gland; gonad; head mesoderm; organism; and trunk mesoderm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG12744 in Genome Data Viewer
Location:
46C1-46C1; 2-61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9874889..9876242)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5762786..5763747)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45138 Neighboring gene pendolino Neighboring gene Linking immunity and metabolism Neighboring gene Secretory 24AB Neighboring gene antisense RNA:CR45467 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The zinc finger protein CG12744 is essential for differentiation and regeneration after infection in the adult Drosophila midgut. Liu Q, et al. Exp Cell Res, 2017 Dec 15. PMID 29074370
  2. The zinc finger protein CG12744 regulates intestinal stem cells in aged Drosophila through the EGFR and BMP pathways. Wang J, et al. Life Sci, 2024 Mar 1. PMID 38311220
  3. Identification of genes involved in the same pathways using a Hidden Markov Model-based approach. Senf A, et al. Bioinformatics, 2009 Nov 15. PMID 19720676
  4. Identification and functional analysis of antifungal immune response genes in Drosophila. Jin LH, et al. PLoS Pathog, 2008 Oct 3. PMID 18833296, Free PMC Article
  5. New Drosophila Long-Term Memory Genes Revealed by Assessing Computational Function Prediction Methods. Kacsoh BZ, et al. G3 (Bethesda), 2019 Jan 9. PMID 30463884, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The zinc finger protein CG12744 regulates intestinal stem cells in aged Drosophila through the EGFR and BMP pathways.
    Title: The zinc finger protein CG12744 regulates intestinal stem cells in aged Drosophila through the EGFR and BMP pathways.
  2. CG12744 maintained epithelial architecture and cell fate in enterocytes following an acute infectious challenge.
    Title: The zinc finger protein CG12744 is essential for differentiation and regeneration after infection in the adult Drosophila midgut.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG12744-PA
CG12744-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9874889..9876242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136686.5 → NP_610530.1  uncharacterized protein Dmel_CG12744, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610530.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUR5
    UniProtKB/TrEMBL
    E2QC93
    Related
    FBpp0087466
    Conserved Domains (1) summary
    sd00017
    Location:12 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_165717.3 → NP_724850.1  uncharacterized protein Dmel_CG12744, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUR5
    UniProtKB/TrEMBL
    E2QC93
    Related
    FBpp0087465
    Conserved Domains (1) summary
    sd00017
    Location:12 → 32
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QC93 E2QC93
Q7JUR5.1 Q7JUR5

Gene LinkOut

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