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Etf-QO Electron transfer flavoprotein-ubiquinone oxidoreductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36031, updated on 9-Dec-2024

Summary

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Official Symbol
Etf-QOprovided by FlyBase
Official Full Name
Electron transfer flavoprotein-ubiquinone oxidoreductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0286783
Locus tag
Dmel_CG12140
See related
AllianceGenome:FB:FBgn0286783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG 12140; CG12140; Dmel\CG12140; ETF:QO; ETFD; ETFDH; EtfQ0; I; l(2)46Ca
Summary
Enables electron-transferring-flavoprotein dehydrogenase activity. Involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in adult head and adult heart. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Etf-QO in Genome Data Viewer
Location:
46C4-46C4; 2-61 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9910893..9913488)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5798398..5800993)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene FMRFamide Neighboring gene Myocyte enhancer factor 2 Neighboring gene Pdrg1 prefoldin-like subunit Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila. Alves E, et al. Biochim Biophys Acta, 2012 Aug. PMID 22580358
  2. The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation. Ishizaki K, et al. Plant Cell, 2005 Sep. PMID 16055629, Free PMC Article
  3. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
  4. The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila. Mendez S, et al. PLoS One, 2016. PMID 27736996, Free PMC Article
  5. A genetic and molecular analysis of the 46C chromosomal region surrounding the FMRFamide neuropeptide gene in Drosophila melanogaster. O'Brien MA, et al. Genetics, 1994 May. PMID 8056304, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron-transferring-flavoprotein dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron-transferring-flavoprotein dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
electron transfer flavoprotein-ubiquinone oxidoreductase
Names
CG12140-PA
CG12140-PB
Etf-QO-PA
Etf-QO-PB
electron transfer flavoprotein:ubiquinone oxidoreductase
group I
lethal (2) 46Ca
NP_001246231.1
NP_610536.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9910893..9913488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136692.1 → NP_610536.1  electron transfer flavoprotein-ubiquinone oxidoreductase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610536.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWF1
    Related
    FBpp0087472, FBtr0088384
    Conserved Domains (3) summary
    COG0644
    Location:56 → 516
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:499 → 602
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:44 → 206
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. NM_001259302.1 → NP_001246231.1  electron transfer flavoprotein-ubiquinone oxidoreductase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246231.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWF1
    Conserved Domains (3) summary
    COG0644
    Location:56 → 516
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    pfam05187
    Location:499 → 602
    ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
    cl21454
    Location:44 → 206
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWF1 Q7JWF1

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