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Ntan1 N-terminal asparagine amidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 360462, updated on 4-Jan-2025

Summary

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Official Symbol
Ntan1provided by RGD
Official Full Name
N-terminal asparagine amidaseprovided by RGD
Primary source
RGD:1305160
See related
EnsemblRapid:ENSRNOG00000080737 AllianceGenome:RGD:1305160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305160
Summary
Predicted to enable protein-N-terminal asparagine amidohydrolase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within adult locomotory behavior and memory. Predicted to be located in cytoplasm and nucleus. Orthologous to human NTAN1 (N-terminal asparagine amidase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 360.6), Kidney (RPKM 336.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ntan1 in Genome Data Viewer
Location:
10q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (2618239..2633185, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (2111090..2126119, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (3218414..3235229)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene bMERB domain containing 1 Neighboring gene nuclear receptor coactivator 4, pseudogene 1 Neighboring gene MPV17 mitochondrial inner membrane protein like Neighboring gene pyridoxal-dependent decarboxylase domain containing 1 Neighboring gene uncharacterized LOC102552514 Neighboring gene RRN3 homolog, RNA polymerase I transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase. Cantor JR, et al. Biochemistry, 2011 Apr 12. PMID 21375249, Free PMC Article
  2. Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway. Kwon YT, et al. Mol Cell Biol, 2000 Jun. PMID 10805755, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC108792

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-N-terminal asparagine amidohydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within memory ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein N-terminal asparagine amidohydrolase
Names
N-terminal Asn amidase
NP_001020295.1
NP_001380620.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025124.2 → NP_001020295.1  protein N-terminal asparagine amidohydrolase isoform 1

    See identical proteins and their annotated locations for NP_001020295.1

    Status: VALIDATED

    Source sequence(s)
    BC091175
    UniProtKB/TrEMBL
    A6K4F6, Q5BK79
    Related
    ENSRNOP00000098729.1, ENSRNOT00000127416.1
    Conserved Domains (1) summary
    pfam14736
    Location:39 → 304
    N_Asn_amidohyd; Protein N-terminal asparagine amidohydrolase

  2. NM_001393691.1 → NP_001380620.1  protein N-terminal asparagine amidohydrolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    FM043276, FM062658, JAXUCZ010000010
    UniProtKB/TrEMBL
    A6K4F7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    2618239..2633185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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