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Nagpa N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 360476, updated on 27-Nov-2024

Summary

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Official Symbol
Nagpaprovided by RGD
Official Full Name
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidaseprovided by RGD
Primary source
RGD:1308972
See related
EnsemblRapid:ENSRNOG00000002895 AllianceGenome:RGD:1308972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in secretion of lysosomal enzymes. Orthologous to human NAGPA (N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 31.6), Adrenal (RPKM 29.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nagpa in Genome Data Viewer
Location:
10q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (10886723..10895066)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10380262..10388609)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10573191..10581516)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor 2 lysine methyltransferase Neighboring gene similar to human chromosome 16 open reading frame 89 Neighboring gene ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase Neighboring gene SEC14-like lipid binding 5 Neighboring gene periplakin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Boonen M, et al. Mol Biol Cell, 2009 Oct. PMID 19710420, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in secretion of lysosomal enzymes IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within secretion of lysosomal enzymes ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NP_001101735.1
XP_038942186.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108265.1 → NP_001101735.1  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

    See identical proteins and their annotated locations for NP_001101735.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474017
    UniProtKB/TrEMBL
    A6K4P0, B5DF88, G3V6D1
    Related
    ENSRNOP00000003888.7, ENSRNOT00000003888.8
    Conserved Domains (1) summary
    pfam09992
    Location:131 → 326
    NAGPA; Phosphodiester glycosidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    10886723..10895066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086258.2 → XP_038942186.1  N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase isoform X1

    Conserved Domains (1) summary
    pfam09992
    Location:131 → 306
    NAGPA; Phosphodiester glycosidase

RNA

  1. XR_005489885.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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