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Smim22 small integral membrane protein 22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360478, updated on 14-Nov-2024

Summary

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Official Symbol
Smim22provided by RGD
Official Full Name
small integral membrane protein 22provided by RGD
Primary source
RGD:1563547
See related
EnsemblRapid:ENSRNOG00000080339 AllianceGenome:RGD:1563547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563547
Summary
Predicted to be involved in several processes, including lipid droplet formation; positive regulation of cell migration; and regulation of actin cytoskeleton organization. Orthologous to human SMIM22 (small integral membrane protein 22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 44.5), Lung (RPKM 18.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Smim22 in Genome Data Viewer
Location:
10q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (11079019..11080804, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (10572146..10574339, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (10766208..10768044, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene glyoxylate reductase 1 homolog Neighboring gene rogdi atypical leucine zipper Neighboring gene septin 12 Neighboring gene dynein axonemal assembly factor 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation. Polycarpou-Schwarz M, et al. Oncogene, 2018 Aug. PMID 29765154
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in lipid droplet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small integral membrane protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108266.1 → NP_001101736.1  small integral membrane protein 22

    See identical proteins and their annotated locations for NP_001101736.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474017
    UniProtKB/TrEMBL
    A6K4P7
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 47
    DUF4713; Domain of unknown function (DUF4713)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    11079019..11080804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245805.5 → XP_006245867.1  small integral membrane protein 22 isoform X1

    See identical proteins and their annotated locations for XP_006245867.1

    UniProtKB/TrEMBL
    A6K4P7
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 47
    DUF4713; Domain of unknown function (DUF4713)

  2. XM_063269291.1 → XP_063125361.1  small integral membrane protein 22 isoform X2

  3. XM_006245806.5 → XP_006245868.1  small integral membrane protein 22 isoform X2

    Related
    ENSRNOP00000111262.1, ENSRNOT00000122592.1
    Conserved Domains (1) summary
    pfam15831
    Location:10 → 47
    DUF4713; Domain of unknown function (DUF4713)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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