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Lmf1 lipase maturation factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360495, updated on 27-Nov-2024

Summary

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Official Symbol
Lmf1provided by RGD
Official Full Name
lipase maturation factor 1provided by RGD
Primary source
RGD:1310180
See related
EnsemblRapid:ENSRNOG00000000230 AllianceGenome:RGD:1310180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310180
Summary
Predicted to be involved in protein maturation and triglyceride metabolic process. Predicted to act upstream of or within several processes, including chylomicron remnant clearance; positive regulation of lipoprotein lipase activity; and regulation of lipid metabolic process. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial lipase maturation factor 1 deficiency. Orthologous to human LMF1 (lipase maturation factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 68.3), Liver (RPKM 61.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lmf1 in Genome Data Viewer
Location:
10q12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15094432..15188665)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14597726..14684071)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14945185..15031855)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095051 Neighboring gene SRY-box transcription factor 8 Neighboring gene uncharacterized LOC120095315 Neighboring gene chromosome transmission fidelity factor 18 Neighboring gene G protein subunit gamma 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate. Forcheron F, et al. Diabetes Metab, 2009 Dec. PMID 19854668
  2. Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion. Boedeker JC, et al. J Lipid Res, 2001 Nov. PMID 11714855
  3. Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum. Park JW, et al. Biochem J, 1996 Jul 1. PMID 8694753, Free PMC Article
  4. Combined lipase deficiency (cld/cld) in mice. Demonstration that an inactive form of lipoprotein lipase is synthesized. Olivecrona T, et al. J Biol Chem, 1985 Feb 25. PMID 3972797
  5. Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion. Davis RC, et al. J Biol Chem, 1990 Oct 15. PMID 2211673

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein maturation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lipase maturation factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427222.1 → NP_001414151.1  lipase maturation factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    Related
    ENSRNOP00000000246.8, ENSRNOT00000000246.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15094432..15188665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269313.1 → XP_063125383.1  lipase maturation factor 1 isoform X1

  2. XM_063269312.1 → XP_063125382.1  lipase maturation factor 1 isoform X1

  3. XM_039087107.2 → XP_038943035.1  lipase maturation factor 1 isoform X2

    Conserved Domains (1) summary
    pfam06762
    Location:1 → 312
    LMF1; Lipase maturation factor

  4. XM_039087108.2 → XP_038943036.1  lipase maturation factor 1 isoform X3

    Conserved Domains (1) summary
    pfam06762
    Location:2 → 299
    LMF1; Lipase maturation factor

  5. XM_063269314.1 → XP_063125384.1  lipase maturation factor 1 isoform X4

RNA

  1. XR_010055201.1 RNA Sequence

  2. XR_010055202.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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