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Ciao3 cytosolic iron-sulfur assembly component 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360496, updated on 27-Nov-2024

Summary

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Official Symbol
Ciao3provided by RGD
Official Full Name
cytosolic iron-sulfur assembly component 3provided by RGD
Primary source
RGD:1305982
See related
EnsemblRapid:ENSRNOG00000019522 AllianceGenome:RGD:1305982
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Narfl
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in several processes, including intracellular oxygen homeostasis; iron-sulfur cluster assembly; and response to hypoxia. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 193.3), Muscle (RPKM 142.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ciao3 in Genome Data Viewer
Location:
10q12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15300403..15309467)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14795888..14804953)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15143732..15152706)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mesothelin-like Neighboring gene mesothelin Neighboring gene hydroxyacylglutathione hydrolase-like Neighboring gene coiled-coil domain containing 78 Neighboring gene adenine nucleotide translocase lysine methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis. Song D, et al. J Biol Chem, 2008 Apr 4. PMID 18270200, Free PMC Article
  2. Mouse knock-out of IOP1 protein reveals its essential role in mammalian cytosolic iron-sulfur protein biogenesis. Song D, et al. J Biol Chem, 2011 May 6. PMID 21367862, Free PMC Article
  3. IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity. Huang J, et al. Biochem J, 2007 Jan 1. PMID 16956324, Free PMC Article
  4. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
  5. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway. Seki M, et al. J Biol Chem, 2013 Jun 7. PMID 23585563, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109005

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular oxygen homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in iron-sulfur cluster assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in iron-sulfur cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of cytosolic [4Fe-4S] assembly targeting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic [4Fe-4S] assembly targeting complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytosolic iron-sulfur assembly component 3
Names
IOP1
cytosolic Fe-S cluster assembly factor NARFL
iron-only hydrogenase-like protein 1
nuclear prelamin A recognition factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013183.1 → NP_001013201.1  cytosolic iron-sulfur assembly component 3

    See identical proteins and their annotated locations for NP_001013201.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091240
    UniProtKB/Swiss-Prot
    Q5BK18
    UniProtKB/TrEMBL
    A6HD46
    Conserved Domains (2) summary
    smart00902
    Location:418 → 466
    Fe_hyd_SSU; Iron hydrogenase small subunit
    pfam02906
    Location:112 → 403
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15300403..15309467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086277.2 → XP_038942205.1  cytosolic iron-sulfur assembly component 3 isoform X3

    Conserved Domains (1) summary
    pfam02906
    Location:112 → 348
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

  2. XM_039086276.2 → XP_038942204.1  cytosolic iron-sulfur assembly component 3 isoform X2

    Related
    ENSRNOP00000108952.1, ENSRNOT00000144894.1
    Conserved Domains (2) summary
    smart00902
    Location:399 → 447
    Fe_hyd_SSU; Iron hydrogenase small subunit
    pfam02906
    Location:93 → 384
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

  3. XM_039086275.2 → XP_038942203.1  cytosolic iron-sulfur assembly component 3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QFN5
    Related
    ENSRNOP00000026518.4, ENSRNOT00000026518.7
    Conserved Domains (2) summary
    smart00902
    Location:413 → 461
    Fe_hyd_SSU; Iron hydrogenase small subunit
    pfam02906
    Location:107 → 398
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain

  4. XM_039086278.2 → XP_038942206.1  cytosolic iron-sulfur assembly component 3 isoform X4

    Conserved Domains (2) summary
    smart00902
    Location:234 → 282
    Fe_hyd_SSU; Iron hydrogenase small subunit
    pfam02906
    Location:1 → 219
    Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK18.1 GenPept UniProtKB/Swiss-Prot:Q5BK18

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