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14-3-3zeta - 14-3-3zeta

Enables molecular sequestering activity; protein dimerization activity; and transcription coactivator binding activity. Involved in several processes, including oocyte differentiation; positive regulation of signal transduction; and protein stabilization. Located in germline ring canal. Is expressed in several structures, including ganglia; gut section; imaginal disc; neuromuscular junction; and synaptic neuropil domain. Used to study intellectual disability. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to several human genes including YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa