Retreg3 reticulophagy regulator family member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Retreg3provided by RGD
Official Full Name: reticulophagy regulator family member 3provided by RGD
Primary source: RGD:1561189
See related: EnsemblRapid:ENSRNOG00000020056 AllianceGenome:RGD:1561189
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam134c; RGD1561189
Summary: Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Predicted to be involved in endoplasmic reticulum tubular network organization and positive regulation of neuron projection development. Predicted to act upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Predicted to be located in endoplasmic reticulum tubular network. Predicted to be part of protein-containing complex. Orthologous to human RETREG3 (reticulophagy regulator family member 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Thymus (RPKM 225.8), Spleen (RPKM 189.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86529048..86552873, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (86028767..86052575, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (89006595..89030595, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI176419 (e-PCR)
- UniSTS:250228

A005R24 (e-PCR)
- UniSTS:17359

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endoplasmic reticulum-autophagosome adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within collagen catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoplasmic reticulum organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum tubular network organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reticulophagy	ISO Inferred from Sequence Orthology more info
involved_in reticulophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: reticulophagy regulator 3

Names: family with sequence similarity 134, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135804.1 → NP_001129276.1 reticulophagy regulator 3

See identical proteins and their annotated locations for NP_001129276.1

Status: PROVISIONAL

Source sequence(s)

BC166581

UniProtKB/TrEMBL

A6HJ86, B2GV94

Related

ENSRNOP00000027217.3, ENSRNOT00000027217.8

Conserved Domains (1) summary

cd22562
Location:41 → 232

RETR3_RHD; N-terminal reticulon-homology domain of Reticulophagy regulator 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86529048..86552873 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086406.1 → XP_038942334.1 reticulophagy regulator 3 isoform X1

Conserved Domains (1) summary

cl41772
Location:1 → 51

Arl6IP1_RETR3-like; ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins