Taco1 translational activator of cytochrome c oxidase I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taco1provided by RGD
Official Full Name: translational activator of cytochrome c oxidase Iprovided by RGD
Primary source: RGD:1306784
See related: EnsemblRapid:ENSRNOG00000008405 AllianceGenome:RGD:1306784
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc44; RGD1306784
Summary: Predicted to enable mRNA binding activity; mitochondrial ribosome binding activity; and rRNA binding activity. Predicted to act upstream of or within several processes, including mitochondrial cytochrome c oxidase assembly; motor learning; and regulation of cytochrome-c oxidase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 8. Orthologous to human TACO1 (translational activator of cytochrome c oxidase I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 144.2), Heart (RPKM 122.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91502395..91510299)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91002590..91010494)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94260148..94268276)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables mitochondrial ribosome binding	IEA Inferred from Electronic Annotation more info
enables mitochondrial ribosome binding	ISO Inferred from Sequence Orthology more info
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables rRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in motor learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within motor learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cytochrome-c oxidase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitochondrial translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: translational activator of cytochrome c oxidase 1

Names: coiled-coil domain containing 44; coiled-coil domain-containing protein 44; translational activator of mitochondrially-encoded cytochrome c oxidase I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.