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Unk unk zinc finger [ Rattus norvegicus (Norway rat) ]

Gene ID: 360663, updated on 4-Jan-2025

Summary

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Official Symbol
Unkprovided by RGD
Official Full Name
unk zinc fingerprovided by RGD
Primary source
RGD:1309224
See related
EnsemblRapid:ENSRNOG00000006600 AllianceGenome:RGD:1309224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zc3h5; Zc3hdc5
Summary
Predicted to enable mRNA CDS binding activity and ribosome binding activity. Predicted to be involved in cell morphogenesis involved in neuron differentiation and negative regulation of cytoplasmic translation. Predicted to act upstream of or within in utero embryonic development and neuron migration. Predicted to be located in cytoplasm. Orthologous to human UNK (unk zinc finger). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 55.0), Spleen (RPKM 45.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Unk in Genome Data Viewer
Location:
10q32.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101764732..101794847)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101265732..101295950)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104582531..104613102)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7-like Neighboring gene H3.3 histone B Neighboring gene uncharacterized LOC134480906 Neighboring gene unc-13 homolog D Neighboring gene WW domain binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wilson R, et al. Wellcome Open Res, 2016. PMID 27996060, Free PMC Article
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA CDS binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell morphogenesis involved in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RING finger protein unkempt homolog
Names
unkempt family zinc finger
unkempt homolog
zinc finger CCCH type containing 5
zinc finger CCCH type domain containing 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430241.1 → NP_001417170.1  RING finger protein unkempt homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ARP1, D3ZV40

  2. NM_001430242.1 → NP_001417171.1  RING finger protein unkempt homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6ARP1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    101764732..101794847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003750953.5 → XP_003751001.1  RING finger protein unkempt homolog isoform X1

    Related
    ENSRNOP00000009733.6, ENSRNOT00000009733.9
    Conserved Domains (4) summary
    COG5063
    Location:124 → 318
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    pfam00642
    Location:294 → 318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam05384
    Location:646 → 719
    DegS; Sensor protein DegS
    pfam13920
    Location:765 → 801
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  2. XM_003750954.6 → XP_003751002.1  RING finger protein unkempt homolog isoform X2

    Conserved Domains (4) summary
    COG5063
    Location:124 → 318
    CTH1; CCCH-type Zn-finger protein [General function prediction only]
    pfam00642
    Location:294 → 318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam05384
    Location:633 → 706
    DegS; Sensor protein DegS
    pfam13920
    Location:752 → 788
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

  3. XM_039087811.2 → XP_038943739.1  RING finger protein unkempt homolog isoform X3

    Conserved Domains (3) summary
    PHA03307
    Location:308 → 571
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam18384
    Location:34 → 69
    zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)
    pfam00642
    Location:294 → 318
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

RNA

  1. XR_005490797.2 RNA Sequence

  2. XR_010055883.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108306.1: Suppressed sequence

    Description
    NM_001108306.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: UNK (GeneID:85451).
Nucleotide Protein Strain
Heading Accession and Version

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