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Vps26c VPS26 endosomal protein sorting factor C [ Rattus norvegicus (Norway rat) ]

Gene ID: 360703, updated on 4-Jan-2025

Summary

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Official Symbol
Vps26cprovided by RGD
Official Full Name
VPS26 endosomal protein sorting factor Cprovided by RGD
Primary source
RGD:1306879
See related
EnsemblRapid:ENSRNOG00000001681 AllianceGenome:RGD:1306879
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dscr3
Summary
Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be active in endosome. Orthologous to human VPS26C (VPS26 endosomal protein sorting factor C). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 96.6), Adrenal (RPKM 95.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Vps26c in Genome Data Viewer
Location:
11q11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (47283764..47311105, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33813467..33841883, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34764053..34792446, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class P Neighboring gene tetratricopeptide repeat domain 3 Neighboring gene U1 spliceosomal RNA Neighboring gene large ribosomal subunit protein uL5-like Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1A Neighboring gene uncharacterized LOC120095638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. McNally KE, et al. Nat Cell Biol, 2017 Oct. PMID 28892079, Free PMC Article
  2. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 26C
Names
DSCR3 arrestin fold containing
Down syndrome critical region 3
Down syndrome critical region gene 3
Down syndrome critical region protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108316.2 → NP_001101786.2  vacuolar protein sorting-associated protein 26C

    See identical proteins and their annotated locations for NP_001101786.2

    Status: PROVISIONAL

    Source sequence(s)
    BC160826
    UniProtKB/TrEMBL
    A0A8I6A9V7, B1H223
    Related
    ENSRNOP00000002284.6, ENSRNOT00000002284.8
    Conserved Domains (1) summary
    cl22903
    Location:1 → 283
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    47283764..47311105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270630.1 → XP_063126700.1  vacuolar protein sorting-associated protein 26C isoform X4

  2. XM_006248072.5 → XP_006248134.1  vacuolar protein sorting-associated protein 26C isoform X2

    UniProtKB/TrEMBL
    A0A8I6A639
    Related
    ENSRNOP00000088383.1, ENSRNOT00000112054.2
    Conserved Domains (1) summary
    cl22903
    Location:1 → 233
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  3. XM_039088476.2 → XP_038944404.1  vacuolar protein sorting-associated protein 26C isoform X3

    Conserved Domains (1) summary
    cl22903
    Location:1 → 176
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  4. XM_008768583.4 → XP_008766805.1  vacuolar protein sorting-associated protein 26C isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9V7
    Conserved Domains (1) summary
    cl22903
    Location:1 → 261
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

  5. XM_039088477.2 → XP_038944405.1  vacuolar protein sorting-associated protein 26C isoform X5

    UniProtKB/TrEMBL
    A6KPW2
    Conserved Domains (1) summary
    cl22903
    Location:1 → 169
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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