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KCNQ KCNQ potassium channel [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36071, updated on 9-Dec-2024

Summary

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Official Symbol
KCNQprovided by FlyBase
Official Full Name
KCNQ potassium channelprovided by FlyBase
Primary source
FLYBASE:FBgn0033494
Locus tag
Dmel_CG33135
See related
AllianceGenome:FB:FBgn0033494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12215; CG12915; CG33135; dKCNQ; DKCNQ; Dmel\CG33135; kcnq1; KCNQ1; KQT; KQT 1
Summary
Enables voltage-gated monoatomic cation channel activity. Involved in several processes, including cardiac muscle contraction; potassium ion transport; and regulation of heart rate. Located in membrane. Is expressed in several structures, including adult brain cell body rind; adult head; egg chamber; female germline cell; and lamina. Used to study heart conduction disease and long QT syndrome. Human ortholog(s) of this gene implicated in auditory system disease (multiple); autistic disorder; autosomal dominant intellectual developmental disorder 46; and electroclinical syndrome (multiple). Orthologous to several human genes including KCNQ4 (potassium voltage-gated channel subfamily Q member 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See KCNQ in Genome Data Viewer
Location:
46F3-46F5; 2-62 cM
Exon count:
21
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10145897..10192394, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6033402..6079899, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43467 Neighboring gene gemini Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 46a Neighboring gene antisense RNA:CR45133 Neighboring gene mulet Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46322 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. KCNQ channels regulate age-related memory impairment. Cavaliere S, et al. PLoS One, 2013. PMID 23638087, Free PMC Article
  2. Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. Cavaliere S, et al. PLoS One, 2011. PMID 21915266, Free PMC Article
  3. Mulet (mlt) encodes a tubulin-binding cofactor E-like homolog required for spermatid individualization in Drosophila melanogaster. Fabrizio JJ, et al. Fly (Austin), 2012 Oct-Dec. PMID 22885996, Free PMC Article
  4. A Drosophila KCNQ channel essential for early embryonic development. Wen H, et al. J Neurosci, 2005 Nov 2. PMID 16267222, Free PMC Article
  5. Drosophila ortholog of succinyl-CoA synthetase {beta} subunit: a novel modulator of Drosophila KCNQ channels. Gao L, et al. J Neurophysiol, 2008 May. PMID 18385479

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c10186043-10176935 mobile_element_type = transposon:roo{}796

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables voltage-gated monoatomic cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic development via the syncytial blastoderm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
KCNQ potassium channel
Names
CG33135-PC
CG33135-PD
CG33135-PE
CG33135-PF
CG33135-PG
CG33135-PH
CG33135-PI
CG33135-PJ
CG33135-PK
KCNQ-PC
KCNQ-PD
KCNQ-PE
KCNQ-PF
KCNQ-PG
KCNQ-PH
KCNQ-PI
KCNQ-PJ
KCNQ-PK
KCNQ-type K[+] channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10145897..10192394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144160.2 → NP_001137632.1  KCNQ potassium channel, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZR3, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:66 → 271
    Ion_trans; Ion transport protein
    pfam03520
    Location:400 → 500
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:187 → 261
    Ion_trans_2; Ion channel

  2. NM_001273919.1 → NP_001260848.1  KCNQ potassium channel, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KF62, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:97 → 302
    Ion_trans; Ion transport protein
    pfam03520
    Location:431 → 531
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:218 → 292
    Ion_trans_2; Ion channel

  3. NM_001273923.1 → NP_001260852.1  KCNQ potassium channel, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260852.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFJ4, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:434 → 534
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel

  4. NM_176119.5 → NP_788299.3  KCNQ potassium channel, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788299.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z855, H1UUH4, Q5PXF9
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:434 → 534
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel

  5. NM_001273922.1 → NP_001260851.1  KCNQ potassium channel, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260851.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEP9, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:453 → 553
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel

  6. NM_001273921.1 → NP_001260850.1  KCNQ potassium channel, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEH2, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:465 → 565
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel

  7. NM_176120.5 → NP_788300.3  KCNQ potassium channel, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788300.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z856, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:619 → 719
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel

  8. NM_001273920.1 → NP_001260849.1  KCNQ potassium channel, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260849.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEI9, H1UUH4
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:449 → 549
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel

  9. NM_001144159.2 → NP_001137631.1  KCNQ potassium channel, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137631.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZR4, Q8IT87
    Conserved Domains (3) summary
    pfam00520
    Location:100 → 305
    Ion_trans; Ion transport protein
    pfam03520
    Location:434 → 534
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:221 → 295
    Ion_trans_2; Ion channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEH2 A0A0B4KEH2
A0A0B4KEI9 A0A0B4KEI9
A0A0B4KEP9 A0A0B4KEP9
A0A0B4KF62 A0A0B4KF62
A0A0B4KFJ4 A0A0B4KFJ4
A1Z856 A1Z856
B7YZR3 B7YZR3
B7YZR4 B7YZR4
Q5PXF9 Q5PXF9
Q8IGU8 Q8IGU8
Q8IT87 Q8IT87

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