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Ess2 ess-2 splicing factor homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 360741, updated on 27-Nov-2024

Summary

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Official Symbol
Ess2provided by RGD
Official Full Name
ess-2 splicing factor homologprovided by RGD
Primary source
RGD:1308218
See related
EnsemblRapid:ENSRNOG00000000283 AllianceGenome:RGD:1308218
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dgcr14
Summary
Predicted to be involved in mRNA splicing, via spliceosome and nervous system development. Predicted to be located in nucleus. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human ESS2 (ess-2 splicing factor homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 77.4), Spleen (RPKM 53.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ess2 in Genome Data Viewer
Location:
11q23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96580185..96596673)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83075893..83085849)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87224371..87234329)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481037 Neighboring gene uncharacterized LOC134481038 Neighboring gene goosecoid homeobox 2 Neighboring gene testis-specific serine kinase 2 Neighboring gene testis-specific serine kinase 1B Neighboring gene DiGeorge syndrome critical region gene 2 Neighboring gene carbonic anhydrase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene. Lindsay EA, et al. Hum Mol Genet, 1998 Apr. PMID 9499415
  2. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109131

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
splicing factor ESS-2 homolog
Names
DiGeorge syndrome critical region gene 14 homolog
DiGeorge syndrome critical region protein 14
protein DGCR14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012472.1 → NP_001012490.1  splicing factor ESS-2 homolog

    See identical proteins and their annotated locations for NP_001012490.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089898
    UniProtKB/TrEMBL
    F7ESE9, Q5EB95
    Related
    ENSRNOP00000000308.5, ENSRNOT00000000308.6
    Conserved Domains (1) summary
    pfam09751
    Location:37 → 405
    Es2; Nuclear protein Es2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    96580185..96596673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248635.5 → XP_006248697.1  splicing factor ESS-2 homolog isoform X1

    UniProtKB/TrEMBL
    F7ESE9
    Conserved Domains (1) summary
    pfam09751
    Location:37 → 404
    Es2; Nuclear protein Es2

RNA

  1. XR_005491045.2 RNA Sequence

  2. XR_005491044.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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