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Usp12 ubiquitin specific peptidase 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360763, updated on 27-Nov-2024

Summary

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Official Symbol
Usp12provided by RGD
Official Full Name
ubiquitin specific peptidase 12provided by RGD
Primary source
RGD:1308045
See related
EnsemblRapid:ENSRNOG00000033411 AllianceGenome:RGD:1308045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in regulation of protein stability. Predicted to act upstream of or within protein deubiquitination. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol and nucleus. Orthologous to human USP12 (ubiquitin specific peptidase 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 176.1), Kidney (RPKM 175.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp12 in Genome Data Viewer
Location:
12p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (13423625..13477547)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (8309845..8363686)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (10037686..10087685)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 102 Neighboring gene ribosomal protein L21 Neighboring gene limb development membrane protein 1-like, pseudogene 1 Neighboring gene uncharacterized LOC134481153 Neighboring gene uncharacterized LOC120095887

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. UAF1 is a subunit of multiple deubiquitinating enzyme complexes. Cohn MA, et al. J Biol Chem, 2009 Feb 20. PMID 19075014, Free PMC Article
  2. H2A-DUBbing the mammalian epigenome: expanding frontiers for histone H2A deubiquitinating enzymes in cell biology and physiology. Belle JI, et al. Int J Biochem Cell Biol, 2014 May. PMID 24647359
  3. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). Gangula NR, et al. J Biol Chem, 2013 Nov 29. PMID 24145035, Free PMC Article
  4. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Jahan AS, et al. Proc Natl Acad Sci U S A, 2016 Feb 9. PMID 26811477, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 12
Names
ubiquitin specific protease 12
ubiquitin thiolesterase 12
NP_001160048.1
XP_038945476.1
XP_063127513.1
XP_063127514.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166576.2 → NP_001160048.1  ubiquitin carboxyl-terminal hydrolase 12

    See identical proteins and their annotated locations for NP_001160048.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1C6, D0RB01, F1LWD4
    Related
    ENSRNOP00000050887.7, ENSRNOT00000044038.7
    Conserved Domains (1) summary
    cd02663
    Location:40 → 367
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    13423625..13477547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089548.2 → XP_038945476.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X2

    UniProtKB/TrEMBL
    A6K1C6
    Conserved Domains (1) summary
    cd02663
    Location:40 → 310
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

  2. XM_063271443.1 → XP_063127513.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X1

  3. XM_063271444.1 → XP_063127514.1  ubiquitin carboxyl-terminal hydrolase 12 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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