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Sdsl serine dehydratase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 360816, updated on 27-Nov-2024

Summary

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Official Symbol
Sdslprovided by RGD
Official Full Name
serine dehydratase-likeprovided by RGD
Primary source
RGD:1309192
See related
EnsemblRapid:ENSRNOG00000001391 AllianceGenome:RGD:1309192
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TDH; Sdhl
Summary
Enables ammonia-lyase activity; glutamate racemase activity; and pyridoxal phosphate binding activity. Predicted to be involved in L-serine catabolic process; isoleucine biosynthetic process; and threonine catabolic process. Orthologous to human SDSL (serine dehydratase like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 26.1), Testes (RPKM 13.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sdsl in Genome Data Viewer
Location:
12q16
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41760252..41770465)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36099693..36109914)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (41636994..41647205)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481191 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase Neighboring gene uncharacterized LOC120095980 Neighboring gene LIM homeobox 5 Neighboring gene RNA binding motif protein 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of an l-serine/l-threonine dehydratase with glutamate racemase activity in mammals. Katane M, et al. Biochem J, 2020 Nov 13. PMID 33079132
  2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine ammonia-lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables glutamate racemase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables threonine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine dehydratase-like
Names
L-serine deaminase
L-serine dehydratase-like
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase
glutamate racemase
NP_001101806.1
XP_038945528.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108336.1 → NP_001101806.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_001101806.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/Swiss-Prot
    A0A6N3IN21, D3ZHV7
    Related
    ENSRNOP00000001882.9, ENSRNOT00000001882.8
    Conserved Domains (1) summary
    cd06448
    Location:17 → 326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41760252..41770465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089600.2 → XP_038945528.1  serine dehydratase-like isoform X1

    Conserved Domains (1) summary
    cl00342
    Location:22 → 276
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6N3IN21.1 GenPept UniProtKB/Swiss-Prot:A0A6N3IN21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials