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Ankle2 ankyrin repeat and LEM domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360829, updated on 4-Jan-2025

Summary

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Official Symbol
Ankle2provided by RGD
Official Full Name
ankyrin repeat and LEM domain containing 2provided by RGD
Primary source
RGD:1310191
See related
EnsemblRapid:ENSRNOG00000060144 AllianceGenome:RGD:1310191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-034; RGD1310191
Summary
Predicted to enable protein kinase inhibitor activity and protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear membrane reassembly; negative regulation of apoptotic process; and negative regulation of phosphorylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 178.0), Lung (RPKM 162.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ankle2 in Genome Data Viewer
Location:
12q16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (52077863..52110775, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (46418142..46451304, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (52475862..52507126, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene peroxisomal membrane protein 2 Neighboring gene PGAM family member 5, mitochondrial serine/threonine protein phosphatase Neighboring gene golgin A3 Neighboring gene uncharacterized LOC134481217 Neighboring gene checkpoint with forkhead and ring finger domains

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A drosophila genetic resource of mutants to study mechanisms underlying human genetic diseases. Yamamoto S, et al. Cell, 2014 Sep 25. PMID 25259927, Free PMC Article
  2. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Asencio C, et al. Cell, 2012 Jul 6. PMID 22770216
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase 2A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 2A binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 2A binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic nuclear membrane reassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic nuclear membrane reassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic nuclear membrane reassembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and LEM domain-containing protein 2
Names
LEM domain-containing protein 4
liver regeneration-related protein LRRG057

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393843.2 → NP_001380772.1  ankyrin repeat and LEM domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    F1LMJ0, F1M1M8, Q7TP65
    Related
    ENSRNOP00000095784.1, ENSRNOT00000101492.2
    Conserved Domains (4) summary
    COG5236
    Location:37 → 184
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd12944
    Location:74 → 116
    LEM_ANKL2; LEM (Lap2/Emerin/Man1) domain found in ankyrin repeat and LEM domain-containing protein 2 (ANKL2)
    sd00045
    Location:419 → 452
    ANK; ANK repeat [structural motif]
    cl39094
    Location:384 → 458
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    52077863..52110775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769343.4 → XP_008767565.3  ankyrin repeat and LEM domain-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ANV5
    Related
    ENSRNOP00000107770.1, ENSRNOT00000130998.1
    Conserved Domains (5) summary
    COG5236
    Location:171 → 318
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    cd12944
    Location:208 → 250
    LEM_ANKL2; LEM (Lap2/Emerin/Man1) domain found in ankyrin repeat and LEM domain-containing protein 2 (ANKL2)
    sd00045
    Location:552 → 585
    ANK; ANK repeat [structural motif]
    pfam01693
    Location:360 → 391
    Cauli_VI; Caulimovirus viroplasmin
    cl39094
    Location:517 → 591
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_063271551.1 → XP_063127621.1  ankyrin repeat and LEM domain-containing protein 2 isoform X2

RNA

  1. XR_005491651.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047901.1: Suppressed sequence

    Description
    NM_001047901.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TP65.2 GenPept UniProtKB/Swiss-Prot:Q7TP65

Gene LinkOut

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