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Mtf2 metal response element binding transcription factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360905, updated on 27-Nov-2024

Summary

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Official Symbol
Mtf2provided by RGD
Official Full Name
metal response element binding transcription factor 2provided by RGD
Primary source
RGD:1304727
See related
EnsemblRapid:ENSRNOG00000000075 AllianceGenome:RGD:1304727
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1304727
Summary
Predicted to enable several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; methylated histone binding activity; and transcription corepressor binding activity. Predicted to be involved in several processes, including negative regulation of gene expression, epigenetic; segment specification; and stem cell population maintenance. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of ESC/E(Z) complex. Predicted to be active in nucleus. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 242.5), Spleen (RPKM 94.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtf2 in Genome Data Viewer
Location:
14p22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1784218..1828463, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1639256..1683513, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2656776..2701027, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene adaptor related protein complex 2 subunit sigma 1, pseudogene 1 Neighboring gene histone cluster 2 H2B family member E, pseudogene 1 Neighboring gene 60S ribosomal protein L34 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. Inouye C, et al. DNA Cell Biol, 1994 Jul. PMID 7772254
  2. Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Musselman CA, et al. Nat Struct Mol Biol, 2012 Dec. PMID 23142980, Free PMC Article
  3. Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. Mididoddi S, et al. Toxicol Lett, 1996 Apr. PMID 8619255
  4. Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes. Li X, et al. Mol Cell Biol, 2011 Jan. PMID 21059868, Free PMC Article
  5. SET for life: biochemical activities and biological functions of SET domain-containing proteins. Herz HM, et al. Trends Biochem Sci, 2013 Dec. PMID 24148750, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in segment specification ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metal-response element-binding transcription factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100898.1 → NP_001094368.1  metal-response element-binding transcription factor 2

    Status: PROVISIONAL

    Source sequence(s)
    BC093403, BC160928, EV774388
    UniProtKB/TrEMBL
    A0A8I6G9Y9, F1LMD5
    Related
    ENSRNOP00000082819.1, ENSRNOT00000114569.2
    Conserved Domains (4) summary
    smart00333
    Location:45 → 95
    TUDOR; Tudor domain
    cd15578
    Location:104 → 156
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:203 → 254
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:544 → 590
    Mtf2_C; Polycomb-like MTF2 factor 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    1784218..1828463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250569.5 → XP_006250631.1  metal-response element-binding transcription factor 2 isoform X2

    UniProtKB/TrEMBL
    B1H2A5
    Conserved Domains (3) summary
    cd15578
    Location:2 → 54
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:101 → 152
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:442 → 488
    Mtf2_C; Polycomb-like MTF2 factor 2

  2. XM_039092150.2 → XP_038948078.1  metal-response element-binding transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSG2, A0A8I6G9Y9
    Related
    ENSRNOP00000081260.1, ENSRNOT00000098983.2
    Conserved Domains (4) summary
    cd15578
    Location:115 → 167
    PHD1_MTF2; PHD finger 1 found in metal-response element-binding transcription factor 2 (MTF2)
    cd15580
    Location:214 → 265
    PHD2_MTF2; PHD finger 2 found in metal-response element-binding transcription factor 2 (MTF2)
    pfam14061
    Location:555 → 602
    Mtf2_C; Polycomb-like MTF2 factor 2
    cd20450
    Location:56 → 109
    Tudor_MTF2; Tudor domain found in metal-response element-binding transcription factor 2 (MTF2) and similar proteins

  3. XM_063273317.1 → XP_063129387.1  metal-response element-binding transcription factor 2 isoform X2

  4. XM_063273316.1 → XP_063129386.1  metal-response element-binding transcription factor 2 isoform X2

  5. XM_063273319.1 → XP_063129389.1  metal-response element-binding transcription factor 2 isoform X2

RNA

  1. XR_005492985.2 RNA Sequence

  2. XR_005492986.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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