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Thoc5 THO complex subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360972, updated on 4-Jan-2025

Summary

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Official Symbol
Thoc5provided by RGD
Official Full Name
THO complex subunit 5provided by RGD
Primary source
RGD:1304991
See related
EnsemblRapid:ENSRNOG00000008456 AllianceGenome:RGD:1304991
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fmip
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus; monocyte differentiation; and primitive hemopoiesis. Predicted to act upstream of or within several processes, including negative regulation of macrophage differentiation; regulation of mRNA export from nucleus; and regulation of stem cell division. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Thymus (RPKM 105.2), Brain (RPKM 93.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Thoc5 in Genome Data Viewer
Location:
14q21
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83982302..84016193)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79758805..79792718)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85138219..85171729)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Neighboring gene nipsnap homolog 1 Neighboring gene U7 small nuclear RNA Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. THOC5 couples M-CSF receptor signaling to transcription factor expression. Carney L, et al. Cell Signal, 2009 Feb. PMID 19015024
  2. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. Mancini A, et al. BMC Biol, 2010 Jan 5. PMID 20051105, Free PMC Article
  3. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). El Bounkari O, et al. FEBS Lett, 2009 Jan 5. PMID 19059247
  4. The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Mancini A, et al. Oncogene, 2004 Aug 26. PMID 15221008
  5. FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation. Tamura T, et al. Oncogene, 1999 Nov 11. PMID 10597251

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in monocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in primitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in primitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of stem cell division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within stem cell division ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of THO complex ISO
Inferred from Sequence Orthology
more info
  
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex part of transcription export complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription export complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
THO complex subunit 5 homolog
Names
Fms interacting protein
THO complex 5
fms-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012153.2 → NP_001012153.1  THO complex subunit 5 homolog isoform 1

    See identical proteins and their annotated locations for NP_001012153.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q68FX7
    UniProtKB/TrEMBL
    A0A8I6AF30
    Related
    ENSRNOP00000011281.8, ENSRNOT00000011281.8
    Conserved Domains (1) summary
    pfam09766
    Location:103 → 451
    FimP; Fms-interacting protein

  2. NM_001401407.1 → NP_001388336.1  THO complex subunit 5 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZVV2, A0A8I6AF30, A6IKJ0
    Related
    ENSRNOP00000103476.1, ENSRNOT00000160359.1

  3. NM_001401408.1 → NP_001388337.1  THO complex subunit 5 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6AF30, A0A8L2Q5G3, A6IKJ1
    Related
    ENSRNOP00000077470.1, ENSRNOT00000115858.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    83982302..84016193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092214.2 → XP_038948142.1  THO complex subunit 5 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8I6AHC9
    Conserved Domains (1) summary
    pfam09766
    Location:81 → 425
    FimP; Fms-interacting protein

  2. XM_039092215.2 → XP_038948143.1  THO complex subunit 5 homolog isoform X2

    UniProtKB/TrEMBL
    A0A8I6AHC9
    Related
    ENSRNOP00000087796.1, ENSRNOT00000110992.2
    Conserved Domains (1) summary
    pfam09766
    Location:81 → 414
    FimP; Fms-interacting protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FX7.1 GenPept UniProtKB/Swiss-Prot:Q68FX7

Gene LinkOut

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