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Tmem17 transmembrane protein 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360985, updated on 9-Dec-2024

Summary

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Official Symbol
Tmem17provided by RGD
Official Full Name
transmembrane protein 17provided by RGD
Primary source
RGD:1310566
See related
EnsemblRapid:ENSRNOG00000009220 AllianceGenome:RGD:1310566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in non-motile cilium assembly and smoothened signaling pathway. Predicted to be located in ciliary membrane. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. Orthologous to human TMEM17 (transmembrane protein 17). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Kidney (RPKM 55.3), Adrenal (RPKM 53.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmem17 in Genome Data Viewer
Location:
14q22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (100684655..100725471)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (96483648..96524238)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (107268235..107308546)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene EH domain binding protein 1 Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene uncharacterized LOC134481801 Neighboring gene uncharacterized LOC134481802 Neighboring gene transfer RNA proline (anticodon AGG) 86 Neighboring gene vasculin-like protein 1-like Neighboring gene ribosomal protein L28 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone. Li C, et al. PLoS Biol, 2016 Mar. PMID 26982032, Free PMC Article
  2. A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Chih B, et al. Nat Cell Biol, 2011 Dec 18. PMID 22179047
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of MKS complex ISO
Inferred from Sequence Orthology
more info
  
part_of MKS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary transition zone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010961.2 → NP_001010961.1  transmembrane protein 17

    See identical proteins and their annotated locations for NP_001010961.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q5HZE5
    UniProtKB/TrEMBL
    A6JQ51
    Conserved Domains (1) summary
    pfam09799
    Location:48 → 151
    Transmemb_17; Predicted membrane protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    100684655..100725471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092230.2 → XP_038948158.1  transmembrane protein 17 isoform X2

    Conserved Domains (1) summary
    pfam09799
    Location:48 → 106
    Transmemb_17; Predicted membrane protein

  2. XM_017599320.3 → XP_017454809.1  transmembrane protein 17 isoform X1

    UniProtKB/Swiss-Prot
    Q5HZE5
    UniProtKB/TrEMBL
    A6JQ51
    Conserved Domains (1) summary
    pfam09799
    Location:48 → 151
    Transmemb_17; Predicted membrane protein

  3. XM_017599321.3 → XP_017454810.1  transmembrane protein 17 isoform X1

    UniProtKB/Swiss-Prot
    Q5HZE5
    UniProtKB/TrEMBL
    A6JQ51
    Related
    ENSRNOP00000012224.3, ENSRNOT00000012224.7
    Conserved Domains (1) summary
    pfam09799
    Location:48 → 151
    Transmemb_17; Predicted membrane protein

  4. XM_063273406.1 → XP_063129476.1  transmembrane protein 17 isoform X1

    UniProtKB/Swiss-Prot
    Q5HZE5
    UniProtKB/TrEMBL
    A6JQ51
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZE5.1 GenPept UniProtKB/Swiss-Prot:Q5HZE5

Gene LinkOut

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