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Dusp13b dual specificity phosphatase 13B [ Rattus norvegicus (Norway rat) ]

Gene ID: 361002, updated on 27-Nov-2024

Summary

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Official Symbol
Dusp13bprovided by RGD
Official Full Name
dual specificity phosphatase 13Bprovided by RGD
Primary source
RGD:1359712
See related
AllianceGenome:RGD:1359712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dusp13
Summary
Predicted to enable MAP kinase phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in dephosphorylation and negative regulation of MAPK cascade. Predicted to be active in cytoplasm. Orthologous to human DUSP13B (dual specificity phosphatase 13B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 231.7), Testes (RPKM 93.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Dusp13b in Genome Data Viewer
Location:
15p16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (2616761..2624434)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (2567432..2575105)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (2524435..2541734)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase domain containing 1 Neighboring gene voltage-dependent anion channel 2 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene uncharacterized LOC108352868 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC120096899 Neighboring gene dual specificity phosphatase 29 Neighboring gene uncharacterized LOC108352871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Nakamura K, et al. Biochem J, 1999 Dec 15. PMID 10585869, Free PMC Article
  2. Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2. Chen HH, et al. J Biol Chem, 2004 Oct 1. PMID 15252030
  3. A growing family of dual specificity phosphatases with low molecular masses. Aoki N, et al. J Biochem, 2001 Jul. PMID 11432789
  4. The family-wide structure and function of human dual-specificity protein phosphatases. Jeong DG, et al. Acta Crystallogr D Biol Crystallogr, 2014 Feb. PMID 24531476
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94474

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS140 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
testis and skeletal muscle-specific dual specificity phosphatase
Names
dual specificity phosphatase 13
dual specificity protein phosphatase 13
NP_001007007.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007006.1 → NP_001007007.1  testis and skeletal muscle-specific dual specificity phosphatase

    See identical proteins and their annotated locations for NP_001007007.1

    Status: VALIDATED

    Source sequence(s)
    BC083646
    UniProtKB/TrEMBL
    Q5XIN2
    Conserved Domains (1) summary
    cl28904
    Location:28 → 191
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    2616761..2624434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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