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CG12895 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36103, updated on 4-Jan-2025

Summary

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Official Symbol
CG12895provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033523
Locus tag
Dmel_CG12895
See related
AllianceGenome:FB:FBgn0033523
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE29446; Dmel\CG12895
Summary
Predicted to be involved in aerobic respiration; mitochondrial respiratory chain complex II assembly; and protein-FAD linkage. Predicted to be active in mitochondrion. Is expressed in embryonic/larval midgut and organism. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG12895 in Genome Data Viewer
Location:
47A7-47A7; 2-62 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10436598..10437382, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6324103..6324887, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ran-binding protein M Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene Chromatin assembly factor 1, p105 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Anti-ageing effects of red ginseng on female Drosophila melanogaster. Hou W, et al. J Cell Mol Med, 2020 Mar. PMID 32022406, Free PMC Article
  2. Mutations of the withered (whd) gene in Drosophila melanogaster confer hypersensitivity to oxidative stress and are lesions of the carnitine palmitoyltransferase I (CPT I) gene. Strub BR, et al. Genome, 2008 Jun. PMID 18521119
  3. A genetic interaction map of cell cycle regulators. Billmann M, et al. Mol Biol Cell, 2016 Apr 15. PMID 26912791, Free PMC Article
  4. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
  5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, succinate to ubiquinone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, succinate to ubiquinone ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex II assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein-FAD linkage IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-FAD linkage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG12895-PA
CG12895-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10436598..10437382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273939.2 → NP_001260868.1  uncharacterized protein Dmel_CG12895, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z897, Q8SYX8
    UniProtKB/TrEMBL
    A0A0B4KF96, H0RNF9
    Conserved Domains (1) summary
    pfam03937
    Location:65 → 138
    Sdh5; Flavinator of succinate dehydrogenase

  2. NM_136742.5 → NP_610586.3  uncharacterized protein Dmel_CG12895, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610586.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z897, Q8SYX8
    UniProtKB/TrEMBL
    A0A0B4KF96, H0RNF9
    Related
    FBpp0087405
    Conserved Domains (1) summary
    pfam03937
    Location:65 → 138
    Sdh5; Flavinator of succinate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KF96 A0A0B4KF96
A1Z897.1 A1Z897

Gene LinkOut

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