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Mrpl52 mitochondrial ribosomal protein L52 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361037, updated on 4-Jan-2025

Summary

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Official Symbol
Mrpl52provided by RGD
Official Full Name
mitochondrial ribosomal protein L52provided by RGD
Primary source
RGD:1309297
See related
EnsemblRapid:ENSRNOG00000039297 AllianceGenome:RGD:1309297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL52 (mitochondrial ribosomal protein L52). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Adrenal (RPKM 224.4), Kidney (RPKM 192.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl52 in Genome Data Viewer
Location:
15p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31852927..31856160)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27882777..27886131)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33069479..33072777)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene OXA1L, mitochondrial inner membrane protein Neighboring gene solute carrier family 7 member 7 Neighboring gene matrix metallopeptidase 14 Neighboring gene uncharacterized LOC102550180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL52
Names
39S ribosomal protein L52, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108375.2 → NP_001101845.2  large ribosomal subunit protein mL52

    See identical proteins and their annotated locations for NP_001101845.2

    Status: VALIDATED

    Source sequence(s)
    BC166922, JAXUCZ010000015
    UniProtKB/TrEMBL
    B2RYV8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    31852927..31856160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599738.3 → XP_017455227.1  large ribosomal subunit protein mL52 isoform X4

  2. XM_039093484.2 → XP_038949412.1  large ribosomal subunit protein mL52 isoform X3

    Conserved Domains (2) summary
    pfam18699
    Location:23 → 51
    MRPL52; Mitoribosomal protein mL52
    cl21454
    Location:3 → 77
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_006251976.5 → XP_006252038.1  large ribosomal subunit protein mL52 isoform X1

    Related
    ENSRNOP00000102648.1, ENSRNOT00000060193.6
    Conserved Domains (1) summary
    pfam18699
    Location:23 → 111
    MRPL52; Mitoribosomal protein mL52

  4. XM_017599737.3 → XP_017455226.1  large ribosomal subunit protein mL52 isoform X2

    UniProtKB/TrEMBL
    A6KGT5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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