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Cyp49a1 Cytochrome P450 49a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36105, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp49a1provided by FlyBase
Official Full Name
Cytochrome P450 49a1provided by FlyBase
Primary source
FLYBASE:FBgn0033524
Locus tag
Dmel_CG18377
See related
AllianceGenome:FB:FBgn0033524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
49a1; CG12894; CG18377; Cyp49A1; Cyp49a1p; Dmel\CG18377
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in several structures, including cercus; embryonic anal pad; embryonic epipharynx; embryonic head; and gut section. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cyp49a1 in Genome Data Viewer
Location:
47A7-47A9; 2-62 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10449350..10458892, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6336855..6346397, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ran-binding protein M Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit o Neighboring gene Chromatin assembly factor 1, p105 subunit Neighboring gene uncharacterized protein Neighboring gene withered

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolution of supergene families associated with insecticide resistance. Ranson H, et al. Science, 2002 Oct 4. PMID 12364796
  2. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article
  3. Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen. Sathyanarayanan S, et al. Genes Dev, 2008 Jun 1. PMID 18519643, Free PMC Article
  4. Mutations of the withered (whd) gene in Drosophila melanogaster confer hypersensitivity to oxidative stress and are lesions of the carnitine palmitoyltransferase I (CPT I) gene. Strub BR, et al. Genome, 2008 Jun. PMID 18521119
  5. Genome-wide screen for modifiers of Na (+) /K (+) ATPase alleles identifies critical genetic loci. Talsma AD, et al. Mol Brain, 2014 Dec 5. PMID 25476251, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 49a1
Names
CG18377-PA
CG18377-PC
CG18377-PD
CG18377-PE
Cyp49a1-PA
Cyp49a1-PC
Cyp49a1-PD
Cyp49a1-PE
cytochrome P450
NP_001246256.1
NP_610588.2
NP_724937.1
NP_995803.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10449350..10458892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136744.4 → NP_610588.2  cytochrome P450 49a1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610588.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZC2, B8A3V2, Q8MZH1, Q8SY18, Q9V5L3
    UniProtKB/TrEMBL
    A0A0B4K7M1
    Related
    FBpp0087403
    Conserved Domains (1) summary
    cl12078
    Location:104 → 565
    p450; Cytochrome P450

  2. NM_001259327.2 → NP_001246256.1  cytochrome P450 49a1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246256.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZC2, B8A3V2, Q8MZH1, Q8SY18, Q9V5L3
    UniProtKB/TrEMBL
    A0A0B4K7M1
    Conserved Domains (1) summary
    cl12078
    Location:104 → 565
    p450; Cytochrome P450

  3. NM_206081.2 → NP_995803.1  cytochrome P450 49a1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995803.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZC2, B8A3V2, Q8MZH1, Q8SY18, Q9V5L3
    UniProtKB/TrEMBL
    A0A0B4K7M1
    Conserved Domains (1) summary
    cl12078
    Location:104 → 565
    p450; Cytochrome P450

  4. NM_165774.3 → NP_724937.1  cytochrome P450 49a1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724937.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V5L3
    Related
    FBpp0087404
    Conserved Domains (1) summary
    cl12078
    Location:33 → 391
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7M1 A0A0B4K7M1
Q9V5L3.3 Q9V5L3

Gene LinkOut

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