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Caf1-105 Chromatin assembly factor 1, p105 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36107, updated on 4-Jan-2025

Summary

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Official Symbol
Caf1-105provided by FlyBase
Official Full Name
Chromatin assembly factor 1, p105 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0033526
Locus tag
Dmel_CG12892
See related
AllianceGenome:FB:FBgn0033526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CAF p105; CAF-1 p105; Caf-105; Caf1; CAF1; Caf1-10; caf1-105; CAF1-105; Caf1-p105; CAF1-p105; CAF1-p75; CAF1-p75/p105; CAF105/75; CAF1p105; CAF1p75; CG12892; dCAF-1-p105; dCAF1-p105; dCAF1-p75; Dmel\CG12892; p105; P105; p105/p75; p75; p75/p105
Summary
Predicted to contribute to histone binding activity. Involved in nucleosome assembly. Part of CAF-1 complex. Orthologous to human CHAF1B (chromatin assembly factor 1 subunit B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Caf1-105 in Genome Data Viewer
Location:
47A9-47A9; 2-62 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10466001..10468540, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6353506..6356045, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene G protein alpha subunit o Neighboring gene Cytochrome P450 49a1 Neighboring gene uncharacterized protein Neighboring gene withered Neighboring gene antisense RNA:CR45134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional Regulators Compete with Nucleosomes Post-replication. Ramachandran S, et al. Cell, 2016 Apr 21. PMID 27062929, Free PMC Article
  2. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Tyler JK, et al. Mol Cell Biol, 1996 Nov. PMID 8887645, Free PMC Article
  3. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Tyler JK, et al. Mol Cell Biol, 2001 Oct. PMID 11533245, Free PMC Article
  4. Maintenance of Heterochromatin by the Large Subunit of the CAF-1 Replication-Coupled Histone Chaperone Requires Its Interaction with HP1a Through a Conserved Motif. Roelens B, et al. Genetics, 2017 Jan. PMID 27838630, Free PMC Article
  5. Epigenetic Regulation of Notch Signaling During Drosophila Development. Wei C, et al. Adv Exp Med Biol, 2020. PMID 32060871

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
    Title: Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to histone binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CAF-1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CAF-1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
chromatin assembly factor 1, p105 subunit
Names
CG12892-PA
Caf1-105-PA
medium subunit of CAF-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10466001..10468540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136745.5 → NP_610589.2  chromatin assembly factor 1, p105 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610589.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z898, S5MJB4
    Related
    FBpp0087402
    Conserved Domains (3) summary
    COG2319
    Location:67 → 446
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:75 → 131
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:13 → 377
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z898 A1Z898
Q9BII5 Q9BII5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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