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Primpol primase and DNA directed polymerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 361147, updated on 4-Jan-2025

Summary

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Official Symbol
Primpolprovided by RGD
Official Full Name
primase and DNA directed polymeraseprovided by RGD
Primary source
RGD:1562119
See related
EnsemblRapid:ENSRNOG00000022320 AllianceGenome:RGD:1562119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc111; RGD1562119
Summary
Predicted to enable chromatin binding activity; nucleotidyltransferase activity; and transition metal ion binding activity. Predicted to be involved in DNA metabolic process; R-loop processing; and response to UV. Predicted to be located in mitochondrion and replication fork. Predicted to be part of DNA-directed RNA polymerase complex. Predicted to be active in mitochondrial matrix and nucleus. Human ortholog(s) of this gene implicated in myopia. Orthologous to human PRIMPOL (primase and DNA directed polymerase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 77.1), Thymus (RPKM 50.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Primpol in Genome Data Viewer
Location:
16q11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52413894..52450975)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (45681252..45715758)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (48863385..48900409)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L4, pseudogene 3 Neighboring gene caspase 3 Neighboring gene centromere protein U Neighboring gene acyl-CoA synthetase long-chain family member 1 Neighboring gene uncharacterized LOC108348397

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Zn-finger domain of human PrimPol is required to stabilize the initiating nucleotide during DNA priming. Martínez-Jiménez MI, et al. Nucleic Acids Res, 2018 May 4. PMID 29608762, Free PMC Article
  2. PrimPol is required for replication reinitiation after mtDNA damage. Torregrosa-Muñumer R, et al. Proc Natl Acad Sci U S A, 2017 Oct 24. PMID 29073063, Free PMC Article
  3. Alternative solutions and new scenarios for translesion DNA synthesis by human PrimPol. Martínez-Jiménez MI, et al. DNA Repair (Amst), 2015 May. PMID 25746449
  4. Molecular dissection of the domain architecture and catalytic activities of human PrimPol. Keen BA, et al. Nucleic Acids Res, 2014 May. PMID 24682820, Free PMC Article
  5. Repriming of DNA synthesis at stalled replication forks by human PrimPol. Mourón S, et al. Nat Struct Mol Biol, 2013 Dec. PMID 24240614

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA primase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA primase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in R-loop processing ISO
Inferred from Sequence Orthology
more info
  
involved_in error-prone translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in replication fork ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA-directed primase/polymerase protein; primase and DNA directed polymerase
Names
coiled-coil domain containing 111
primase and polymerase (DNA-directed)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432823.1 → NP_001419752.1  primase and DNA directed polymerase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D4A8C0

  2. NM_001432824.1 → NP_001419753.1  primase and DNA directed polymerase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    D4A8C0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    52413894..52450975
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253167.5 → XP_006253229.1  DNA-directed primase/polymerase protein

    Conserved Domains (2) summary
    pfam03121
    Location:384 → 448
    Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
    cd22256
    Location:459 → 531
    PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

  2. XM_341433.9 → XP_341434.3  DNA-directed primase/polymerase protein

    Related
    ENSRNOP00000107697.1, ENSRNOT00000150556.1
    Conserved Domains (2) summary
    pfam03121
    Location:384 → 448
    Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
    cd22256
    Location:459 → 531
    PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

  3. XM_039094880.2 → XP_038950808.1  DNA-directed primase/polymerase protein

    UniProtKB/TrEMBL
    D4A8C0
    Conserved Domains (2) summary
    pfam03121
    Location:384 → 448
    Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
    cd22256
    Location:459 → 531
    PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

  4. XM_039094879.2 → XP_038950807.1  DNA-directed primase/polymerase protein

    UniProtKB/TrEMBL
    D4A8C0
    Conserved Domains (2) summary
    pfam03121
    Location:384 → 448
    Herpes_UL52; Herpesviridae UL52/UL70 DNA primase
    cd22256
    Location:459 → 531
    PrimPol_RBD; C-terminal RPA-binding domain (RBD) of DNA-directed primase/polymerase protein and similar proteins

  5. XM_063275860.1 → XP_063131930.1  DNA-directed primase/polymerase protein

    UniProtKB/TrEMBL
    D4A8C0

RNA

  1. XR_005494696.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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