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Grtp1 growth hormone regulated TBC protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361180, updated on 4-Jan-2025

Summary

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Official Symbol
Grtp1provided by RGD
Official Full Name
growth hormone regulated TBC protein 1provided by RGD
Primary source
RGD:1309210
See related
EnsemblRapid:ENSRNOG00000071336 AllianceGenome:RGD:1309210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRGT00052
Summary
Predicted to enable GTPase activator activity. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Kidney (RPKM 205.4), Muscle (RPKM 140.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Grtp1 in Genome Data Viewer
Location:
16q12.5
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83034931..83056589)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76332777..76356414)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81665533..81689525)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein 1 light chain 3 beta, pseudogene 1 Neighboring gene uncharacterized LOC102548586 Neighboring gene lysosomal-associated membrane protein 1 Neighboring gene uncharacterized LOC134482532 Neighboring gene cullin 4A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116122

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
growth hormone-regulated TBC protein 1
Names
GH regulated TBC protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031813.2 → NP_001026983.1  growth hormone-regulated TBC protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001026983.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC097985, CB315310
    UniProtKB/Swiss-Prot
    Q4QQU7
    UniProtKB/TrEMBL
    A0A8L2QWJ1
    Related
    ENSRNOP00000065337.2, ENSRNOT00000073240.5
    Conserved Domains (1) summary
    pfam00566
    Location:67 → 231
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. NM_001170477.2 → NP_001163948.1  growth hormone-regulated TBC protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001163948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6IWJ1, D4A2E4
    Related
    ENSRNOP00000026546.6, ENSRNOT00000026546.10
    Conserved Domains (1) summary
    smart00164
    Location:71 → 284
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    83034931..83056589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094683.2 → XP_038950611.1  growth hormone-regulated TBC protein 1 isoform X1

    Related
    ENSRNOP00000110009.1, ENSRNOT00000134093.1
    Conserved Domains (1) summary
    pfam00566
    Location:67 → 157
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. XM_063275574.1 → XP_063131644.1  growth hormone-regulated TBC protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQU7.1 GenPept UniProtKB/Swiss-Prot:Q4QQU7

Gene LinkOut

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