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Slc66a2 solute carrier family 66 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361352, updated on 27-Nov-2024

Summary

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Official Symbol
Slc66a2provided by RGD
Official Full Name
solute carrier family 66 member 2provided by RGD
Primary source
RGD:1305223
See related
EnsemblRapid:ENSRNOG00000059215 AllianceGenome:RGD:1305223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pqlc1
Summary
Predicted to be involved in phospholipid translocation and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and membrane. Predicted to be active in endosome and trans-Golgi network. Orthologous to human SLC66A2 (solute carrier family 66 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 168.8), Liver (RPKM 158.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc66a2 in Genome Data Viewer
Location:
18q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (75976000..76014651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (73702472..73739678)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (76768466..76805773)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene thioredoxin-like 4A Neighboring gene N(alpha)-acetyltransferase 12, NatA catalytic subunit Neighboring gene heat shock factor binding protein 1-like 1 Neighboring gene potassium voltage-gated channel modifier subfamily G member 2 Neighboring gene uncharacterized LOC120098179 Neighboring gene uncharacterized LOC134482964

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 66 member 2
Names
PQ loop repeat containing 1
PQ-loop repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398665.1 → NP_001385594.1  solute carrier family 66 member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8L2UR94, A6K5H3
    Conserved Domains (1) summary
    pfam04193
    Location:152 → 212
    PQ-loop; PQ loop repeat

  2. NM_001398666.1 → NP_001385595.1  solute carrier family 66 member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A8L2UR94, A6K5H3
    Related
    ENSRNOP00000074262.2, ENSRNOT00000089389.3
    Conserved Domains (1) summary
    pfam04193
    Location:152 → 212
    PQ-loop; PQ loop repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    75976000..76014651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254952.5 → XP_006255014.1  solute carrier family 66 member 2 isoform X1

    See identical proteins and their annotated locations for XP_006255014.1

    UniProtKB/Swiss-Prot
    Q5M880
    UniProtKB/TrEMBL
    A6K5H2
    Conserved Domains (1) summary
    pfam04193
    Location:170 → 230
    PQ-loop; PQ loop repeat

  2. XM_006254953.5 → XP_006255015.1  solute carrier family 66 member 2 isoform X1

    See identical proteins and their annotated locations for XP_006255015.1

    UniProtKB/Swiss-Prot
    Q5M880
    UniProtKB/TrEMBL
    A6K5H2
    Related
    ENSRNOP00000086993.1, ENSRNOT00000114669.2
    Conserved Domains (1) summary
    pfam04193
    Location:170 → 230
    PQ-loop; PQ loop repeat

  3. XM_063277484.1 → XP_063133554.1  solute carrier family 66 member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2UR94, A6K5H3

  4. XM_017601004.3 → XP_017456493.1  solute carrier family 66 member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5M880
    UniProtKB/TrEMBL
    A6K5H2
    Conserved Domains (1) summary
    pfam04193
    Location:170 → 230
    PQ-loop; PQ loop repeat

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013189.2: Suppressed sequence

    Description
    NM_001013189.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M880.2 GenPept UniProtKB/Swiss-Prot:Q5M880

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials