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mms4 Methyl methanesulfonate sensitivity 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36136, updated on 4-Jan-2025

Summary

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Official Symbol
mms4provided by FlyBase
Official Full Name
Methyl methanesulfonate sensitivity 4provided by FlyBase
Primary source
FLYBASE:FBgn0033549
Locus tag
Dmel_CG12936
See related
AllianceGenome:FB:FBgn0033549
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12936; Dmel\CG12936; EME1
Summary
Predicted to enable DNA binding activity and nuclease activity. Predicted to be involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of Holliday junction resolvase complex. Is expressed in organism. Orthologous to several human genes including EME1 (essential meiotic structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See mms4 in Genome Data Viewer
Location:
47C1-47C1; 2-63 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10811078..10812215)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6698583..6699720)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene windei Neighboring gene uncharacterized protein Neighboring gene Nop10 ribonucleoprotein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene diego

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis. Trowbridge K, et al. Genetics, 2007 Aug. PMID 17603121, Free PMC Article
  2. Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors. Rawal CC, et al. Histochem Cell Biol, 2024 Jul. PMID 38888809, Free PMC Article
  3. DNA Repair in Drosophila: Mutagens, Models, and Missing Genes. Sekelsky J. Genetics, 2017 Feb. PMID 28154196, Free PMC Article
  4. Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. Barclay SS, et al. Hum Mol Genet, 2014 Mar 1. PMID 24179173
  5. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Kondo S, et al. Sci Signal, 2011 Jan 4. PMID 21205937, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Holliday junction resolvase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
methyl methanesulfonate sensitivity 4
Names
CG12936-PA
methyl methanesulfonate sensitivity 4 ortholog
mms4-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10811078..10812215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136767.3 → NP_610611.1  methyl methanesulfonate sensitivity 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z8C0, Q7JZM5
    Related
    FBpp0087317
    Conserved Domains (1) summary
    pfam02732
    Location:48 → 179
    ERCC4; ERCC4 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z8C0 A1Z8C0
Q7JZM5 Q7JZM5

Gene LinkOut

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