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Anapc10 anaphase promoting complex subunit 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361389, updated on 9-Dec-2024

Summary

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Official Symbol
Anapc10provided by RGD
Official Full Name
anaphase promoting complex subunit 10provided by RGD
Primary source
RGD:1308936
See related
EnsemblRapid:ENSRNOG00000018296 AllianceGenome:RGD:1308936
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in anaphase-promoting complex-dependent catabolic process and protein polyubiquitination. Predicted to be located in cytoplasm. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC10 (anaphase promoting complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Thymus (RPKM 55.3), Lung (RPKM 41.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anapc10 in Genome Data Viewer
Location:
19q11
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (45057278..45109882, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (28152299..28205552, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (31814686..31867928, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene Hedgehog-interacting protein Neighboring gene uncharacterized LOC134483635 Neighboring gene uncharacterized LOC102549584 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene ATP binding cassette subfamily E member 1 Neighboring gene OTU deubiquitinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Ray D, et al. Biol Reprod, 2012 Apr. PMID 22190705, Free PMC Article
  2. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
  3. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. Grossberger R, et al. J Biol Chem, 1999 May 14. PMID 10318877
  4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
  5. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108445.1 → NP_001101915.1  anaphase-promoting complex subunit 10

    See identical proteins and their annotated locations for NP_001101915.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/TrEMBL
    A6IYH7, B5DEP3, F7EP70
    Related
    ENSRNOP00000024689.4, ENSRNOT00000024689.7
    Conserved Domains (1) summary
    pfam03256
    Location:4 → 183
    ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    45057278..45109882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278119.1 → XP_063134189.1  anaphase-promoting complex subunit 10 isoform X2

  2. XM_008772516.4 → XP_008770738.1  anaphase-promoting complex subunit 10 isoform X1

    Conserved Domains (1) summary
    cl02148
    Location:4 → 110
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
Nucleotide Protein Strain
Heading Accession and Version

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